Rojas Romina, Vicente Benjamín, Saldivia Sandra, Melipillán Roberto, Aedo Geraldine, Hormazabal Naín, Carroza Ana
Rev Med Chil. 2015 Oct;143(10):1252-9. doi: 10.4067/S0034-98872015001000003.
Serotonin plays a central role regulating mood and on the development of depressive disorders.
To study whether 5HTTLPR functional polymorphisms in the serotonin transporter gene or the Monoamine oxidase A gene (uMAOA) were risk markers for depression.
The Composite International Diagnostic Interview (CIDI) was applied to 1,062 consultants in primary health care centers aged between 18 and 75 years to establish the diagnosis of depression. A sample of saliva was obtained for DNA extraction and genetic analyses.
No association between the presence of depressive disorders and 5HTTLPR (ss) or uMAOA (3/3) risk genotypes was found. Psychological abuse and the presence of two or more life events were found to be predictors of depression in the studied sample.
In this study, 5HTTLPR and uMAOA polymorphisms were not risk factors for depression. However, psychological abuse and the presence of two or more life events were risk factors for depressive disorders.
血清素在调节情绪及抑郁症的发展过程中起着核心作用。
研究血清素转运体基因或单胺氧化酶A基因（uMAOA）中的5HTTLPR功能多态性是否为抑郁症的风险标志物。
对1062名年龄在18至75岁之间的初级卫生保健中心咨询者应用复合国际诊断访谈（CIDI）来确立抑郁症诊断。采集唾液样本用于DNA提取和基因分析。
未发现抑郁症的存在与5HTTLPR（ss）或uMAOA（3/3）风险基因型之间存在关联。在研究样本中，心理虐待以及存在两个或更多生活事件被发现是抑郁症的预测因素。
在本研究中，5HTTLPR和uMAOA多态性并非抑郁症的风险因素。然而，心理虐待以及存在两个或更多生活事件是抑郁症的风险因素。
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