HIV-1 gp120内部结构域的一个高度保守残基对抗A簇抗体介导的抗体依赖性细胞毒性反应很重要。
A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.
作者信息
Ding Shilei, Veillette Maxime, Coutu Mathieu, Prévost Jérémie, Scharf Louise, Bjorkman Pamela J, Ferrari Guido, Robinson James E, Stürzel Christina, Hahn Beatrice H, Sauter Daniel, Kirchhoff Frank, Lewis George K, Pazgier Marzena, Finzi Andrés
机构信息
Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
出版信息
J Virol. 2015 Dec 4;90(4):2127-34. doi: 10.1128/JVI.02779-15. Print 2016 Feb 15.
Abstract
Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.
摘要
先前的研究表明，来自HIV-1感染者的血清含有能够介导抗体依赖性细胞毒性（ADCC）的抗体。这些抗体优先识别CD4结合后诱导产生的包膜糖蛋白（Env）表位。在此，我们表明，gp120内部结构域第69位的一个高度保守的色氨酸对于由抗A簇抗体和来自HIV-1感染者的血清介导的ADCC很重要。
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