标准泻药在羟考酮使用期间预防和治疗阿片类药物引起的便秘的疗效：一项小型荷兰观察性试点研究。
The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study.
作者信息
Koopmans-Klein Gineke, Wagemans Michel F M, Wartenberg Hans C H, Van Megen Yvonne J B, Huygen Frank J P M
机构信息
a Medical Department , Mundipharma Pharmaceuticals BV , Hoevelaken , The Netherlands.
b Center for Pain Medicine , Erasmus MC , Rotterdam , The Netherlands.
出版信息
Expert Rev Gastroenterol Hepatol. 2016;10(4):547-53. doi: 10.1586/17474124.2016.1129275. Epub 2015 Dec 26.
BACKGROUND
Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC).
METHODS
Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone.
RESULTS
Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT.
CONCLUSION
This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC.
背景
荷兰临床指南建议，开始阿片类药物治疗时应同时开具标准泻药治疗（SLT），以预防阿片类药物引起的便秘（OIC）。
方法
缺乏SLT治疗OIC的临床证据，因此开展了一项观察性试点研究，以探讨SLT对接受阿片类药物羟考酮治疗患者的OIC的疗效和耐受性。
结果
24例患者（58%为女性，年龄中位数（范围）为65岁（39 - 92岁））纳入了该试点研究。分析显示，21例患者中有9例（43%）对SLT无反应。若将有腹泻倾向的患者也考虑在内，则75%的患者对SLT无反应。
结论
该试点研究表明，最佳泻药治疗（SLT）可能对预防和治疗OIC无效且不可行。
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