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心血管危险因素与听力损失:HUNT研究。

Cardiovascular risk factors and hearing loss: The HUNT study.

作者信息

Engdahl Bo, Aarhus Lisa, Lie Arve, Tambs Kristian

机构信息

a Division of Mental Health , Norwegian Institute of Public Health , Nydalen , Oslo , Norway.

b National Institute of Occupational Health , Department of Occupational Medicine and Epidemiology , Oslo , Norway.

出版信息

Int J Audiol. 2015;54(12):958-66. doi: 10.3109/14992027.2015.1090631. Epub 2015 Oct 8.

Abstract

OBJECTIVE

The purpose of the present paper was to examine the association between prospectively and cross-sectionally assessed cardiovascular risk factors and hearing loss.

DESIGN

Hearing was assessed by pure-tone average thresholds at low (0.25-0.5 kHz), middle (1-2 kHz), and high (3-8 kHz) frequencies. Self-reported or measured cardiovascular risk factors were assessed both 11 years before and simultaneously with the audiometric assessment. Cardiovascular risk factors were smoking, alcohol use, physical inactivity, waist circumference, body mass index, resting heart rate, blood pressure, triglycerides, total serum cholesterol, LDL cholesterol, HDL cholesterol, and diabetes.

STUDY SAMPLE

A population-based cohort of 31 547 subjects.

RESULTS

After adjustment for age, sex, level of education, income, recurrent ear infections, and noise exposure, risk factors associated with poorer hearing sensitivity were smoking, diabetes, physical inactivity, resting heart rate, and waist circumference. Smoking was only associated with hearing loss at high frequencies. The effects were very small, in combination explaining only 0.2-0.4% of the variance in addition to the component explained by age and the other cofactors.

CONCLUSION

This cohort study indicates that, although many cardiovascular risk factors are associated with hearing loss, the effects are small and of doubtful clinical relevance.

摘要

目的

本文旨在研究前瞻性和横断面评估的心血管危险因素与听力损失之间的关联。

设计

通过低频率(0.25 - 0.5千赫兹)、中频率(1 - 2千赫兹)和高频率(3 - 8千赫兹)的纯音平均阈值评估听力。在听力测定评估前11年及同时对自我报告或测量的心血管危险因素进行评估。心血管危险因素包括吸烟、饮酒、身体活动不足、腰围、体重指数、静息心率、血压、甘油三酯、总血清胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和糖尿病。

研究样本

基于人群的31547名受试者队列。

结果

在对年龄、性别、教育程度、收入、复发性耳部感染和噪声暴露进行调整后,与听力敏感度较差相关的危险因素为吸烟、糖尿病、身体活动不足、静息心率和腰围。吸烟仅与高频听力损失相关。这些影响非常小,除了年龄和其他协变量所解释的部分外,共同仅解释了0.2 - 0.4%的方差。

结论

这项队列研究表明,尽管许多心血管危险因素与听力损失有关,但影响很小且临床相关性存疑。

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