Jia Li, Jia Qingling, Shang Yonggang, Dong Xingyou, Li Longkun
Department of urology, Xinqiao Hospital, Third Military University, Chongqing, 40037, China.
Department of Nephrology, Xinqiao Hospital, Third Military University, Chongqing, 40037, China.
Sci Rep. 2015 Dec 8;5:17921. doi: 10.1038/srep17921.
Studies have showed that vitamin C intake is linked to renal cell carcinoma risk, however, the results were inconsistent. Hence, the present meta-analysis was to examine the association between vitamin C intake and RCC risk. We searched the published studies that reported the relationship between vitamin C intake and RCC risk using PubMed and Embase up to January 2015. Based on a fixed effects model, RR and the corresponding 95% CI were used to assess the pooled risk. 3 prospective cohort studies and 7 case-control studies were included. The overall RR (95% CI) of RCC for the highest vs. the lowest levels of vitamin C intake was 0.78(0.69,0.87). Little evidence of heterogeneity was found. In the subgroup analyses, we found an inverse association between vitamin C intake and RCC risk in the case-control studies but not in the prospective cohort studies. Additionally, this association between vitamin C intake and RCC risk was not differed by population distribution. Our study provides evidence that vitamin C intake is associated with a reduced RCC risk. However, our conclusion was just based on ten including studies, so more high-quality of case-control studies or cohort studies which report this topic are needed.
研究表明，维生素C的摄入量与肾细胞癌风险相关，但结果并不一致。因此，本荟萃分析旨在研究维生素C摄入量与肾细胞癌风险之间的关联。我们检索了截至2015年1月在PubMed和Embase上发表的报道维生素C摄入量与肾细胞癌风险关系的研究。基于固定效应模型，采用相对危险度（RR）及相应的95%置信区间（CI）评估合并风险。纳入了3项前瞻性队列研究和7项病例对照研究。维生素C摄入量最高组与最低组相比，肾细胞癌的总体RR（95%CI）为0.78（0.69，0.87）。未发现明显的异质性证据。在亚组分析中，我们发现病例对照研究中维生素C摄入量与肾细胞癌风险呈负相关，而在前瞻性队列研究中未发现此关联。此外，维生素C摄入量与肾细胞癌风险之间的这种关联在不同人群分布中并无差异。我们的研究提供了证据表明维生素C摄入量与降低肾细胞癌风险相关。然而，我们的结论仅基于10项纳入研究，因此需要更多高质量的报道该主题的病例对照研究或队列研究。
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