Lu Yong-Chen, Robbins Paul F
Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10-CRC, Rm 3W-3864, 10 Center Dr, MSC 1201, Bethesda, MD 20892, United States.
Semin Immunol. 2016 Feb;28(1):22-7. doi: 10.1016/j.smim.2015.11.002. Epub 2015 Nov 30.
Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.
新抗原是由肿瘤特异性突变基因编码的抗原。过去几年的研究表明新抗原在癌症免疫治疗中起关键作用。在此,我们回顾过去二十年中新抗原的发现以及新抗原鉴定的当前进展。我们还讨论了针对新抗原开发有效的癌症免疫疗法的潜在益处和障碍。