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食品接触材料中的双酚A(BPA)——欧洲食品安全局关于公共卫生风险的新科学意见。

Bisphenol A (BPA) in food contact materials - new scientific opinion from EFSA regarding public health risk.

作者信息

Ćwiek-Ludwicka Kazimiera

机构信息

National Institute of Public Health - National Institute of Hygiene, Chocimska street 24, 00-791 Warsaw, Poland.

出版信息

Rocz Panstw Zakl Hig. 2015;66(4):299-307.

Abstract

The wide use of bisphenol A (BPA) as a monomer in plastics manufacture or epoxy resins intended for food contact materials (FCM) has triggered numerous concerns due to toxicological findings indicating possible endocrine disrupting properties. This article traces the evolution of the scientific opinions since 1986 when the Tolerable Daily Intake (TDI) for BPA and its specific migration limit (SML) from plastic FCM into food were proposed for the first time by the Scientific Committee for Food (SCF). Resent extensive scientific studies concerning refined data on toxicity and exposure to BPA from food and non-food sources (eg. dust, cosmetics, thermal paper), including the most vulnerable groups of population, allowed the European Food Safety Authority (EFSA) to reduce the TDI of BPA from previously 50 µg/kg bw/day to now 4 µg/kg bw/day. EFSA's latest scientific opinion published in 2015 concludes that basing on the current estimations of total exposure to BPA from dietary and non-dietary sources for infants, children and adolescents is below the temporary TDI of 4 μg/kg bw/day. EFSA has also underlined that BPA poses no health risk at the estimated exposure levels of any population age group, including unborn children and the elderly. However, EFSA has indicated that some data on exposure and toxicological effects still require clarifications.

摘要

双酚A(BPA)作为一种单体被广泛应用于塑料制造或用于食品接触材料(FCM)的环氧树脂中,由于毒理学研究结果表明其可能具有内分泌干扰特性,引发了众多关注。本文追溯了自1986年以来科学观点的演变历程,当时食品科学委员会(SCF)首次提出了双酚A的每日可耐受摄入量(TDI)及其从塑料食品接触材料向食品中的特定迁移限量(SML)。最近,针对食品和非食品来源(如灰尘、化妆品、热敏纸)中双酚A的毒性和暴露的精确数据开展了广泛的科学研究,其中包括最脆弱的人群,这使得欧洲食品安全局(EFSA)将双酚A的每日可耐受摄入量从之前的50微克/千克体重/天降低至目前的4微克/千克体重/天。欧洲食品安全局于2015年发布的最新科学意见得出结论,基于目前对婴儿、儿童和青少年从饮食和非饮食来源接触双酚A总量的估计,低于4微克/千克体重/天的临时每日可耐受摄入量。欧洲食品安全局还强调,在任何人群年龄组的估计接触水平下,双酚A都不会构成健康风险,包括未出生的婴儿和老年人。然而,欧洲食品安全局指出,一些关于接触和毒理学效应的数据仍需进一步阐明。

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