Wollberg Z, Bdolah A, Kochva E
Department of Zoology, Tel Aviv University, Israel.
Biochem Biophys Res Commun. 1989 Jul 14;162(1):371-6. doi: 10.1016/0006-291x(89)92006-8.
The sarafotoxins SRTX-a, b and c from the venom of the snake Atractaspis engaddensis are 21-amino acid peptides that affect the cardiovascular system. They are strong vasoconstrictors, the potency of which may be in correlation with their primary structure: SRTX-a, which differs from SRTX-b in a single amino acid residue (Asn instead of Tyr), shows about half of its maximal vasoconstriction, while SRTX-c, which differs in 3 additional residues is a very weak vasoconstrictor and, at high doses, shows vasodilatory effects. Sequential application of the three isotoxins result in a summated response.
来自以色列穴蝰蛇毒液的沙拉毒素SRTX-a、b和c是影响心血管系统的21个氨基酸的肽。它们是强效血管收缩剂，其效力可能与其一级结构相关：SRTX-a与SRTX-b仅在一个氨基酸残基上不同（天冬酰胺而非酪氨酸），其最大血管收缩作用约为SRTX-b的一半，而在另外3个残基上不同的SRTX-c是一种非常弱的血管收缩剂，在高剂量时表现出血管舒张作用。三种同毒素的连续应用会产生累加反应。
