Kannan Umashankkar, Reddy Vemuru Sunil K, Mukerji Amar N, Parithivel Vellore S, Shah Ajay K, Gilchrist Brian F, Farkas Daniel T
Umashankkar Kannan, Vemuru Sunil K Reddy, Amar N Mukerji, Vellore S Parithivel, Ajay K Shah, Brian F Gilchrist, Daniel T Farkas, Department of Surgery, Bronx-Lebanon Hospital Center, Bronx, NY 10457, United States.
World J Gastroenterol. 2015 Dec 7;21(45):12843-50. doi: 10.3748/wjg.v21.i45.12843.
To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons - National Surgical Quality Improvement Program (ACS NSQIP) database.
The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar pre-operative comorbidities. Outcomes including post-operative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ(2) and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable.
The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009 (43%) of the cases were done laparoscopically and 15595 (57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic (LC) and open colectomy (OC) cohorts. The laparoscopic approach had lower post-operative complications (LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay (LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality (LC 1.6%, OC 2.9%, P < 0.001).
Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach.
利用美国外科医师学会-国家外科质量改进计划(ACS NSQIP)数据库,比较65岁及以上老年患者行部分结肠切除术时腹腔镜手术与开放手术的疗效。
查询2005 - 2011年ACS NSQIP数据库中所有65岁及以上接受部分结肠切除术的患者。采用最近邻法进行1:1倾向评分匹配,以确保两组患者术前合并症相似。比较腹腔镜组和开放手术组的术后并发症、住院时间和死亡率等结局指标。离散变量采用χ(2)检验和Fisher精确检验,连续变量采用Student t检验。P < 0.05被认为具有统计学意义,适用时报告比值比及95%置信区间。
2005 - 2011年ACS NSQIP数据库中的患者总数为1777035例。我们确定了27604例接受部分结肠切除术且数据集完整的老年患者。其中12009例(43%)为腹腔镜手术,15595例(57%)为开放手术。倾向评分匹配后,腹腔镜结肠切除术(LC)组和开放结肠切除术(OC)组各有11008例患者。腹腔镜手术组术后并发症发生率较低(LC为15.2%,OC为23.8%,P < 0.001),住院时间较短(LC为6.61天,OC为9.62天,P < 0.001),死亡率较低(LC为1.6%,OC为2.9%,P < 0.001)。
即使经过倾向评分匹配,ACS NSQIP数据库中接受腹腔镜部分结肠切除术的老年患者的疗效仍优于接受开放结肠切除术的患者。在没有特定禁忌证的情况下,需要行部分结肠切除术的老年患者应选择腹腔镜手术方式。