Bredenkamp Angela, Wegener Michael, Hummel Sara, Häring Andreas P, Kirsch Stefan F
Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany.
Chem Commun (Camb). 2016 Jan 31;52(9):1875-8. doi: 10.1039/c5cc09328g.
A versatile process for the construction of 1,3-polyols, a key structural element of polyketide-type natural products, is presented. The modular synthesis strategy involves the iterative chain elongation with novel four-carbon building blocks to access all possible stereoisomers of a growing 1,3-polyol chain. These chiral building blocks are designed to install four carbon atoms with two stereogenic centres by performing only four experimentally simple steps per elongation cycle, thus making these building blocks attractive for the realization of a universal platform from which to access a diverse range of polyketidic molecules.
本文介绍了一种用于构建1,3 -多元醇（聚酮类天然产物的关键结构元素）的通用方法。模块化合成策略涉及使用新型四碳结构单元进行迭代链延长，以获得不断增长的1,3 -多元醇链的所有可能立体异构体。这些手性结构单元被设计为通过每个延长循环仅执行四个实验上简单的步骤来安装具有两个立体中心的四个碳原子，从而使这些结构单元对于实现一个通用平台具有吸引力，从该平台可以获取各种聚酮类分子。
