Division of Functional Neurosurgery of Institute of Psychiatry, Department of Neurology, University of São Paulo Medical School; and.
Laboratory of Neuromodulation, Institute of Teaching and Research, Hospital Sirio-Libanês, São Paulo, Brazil.
J Neurosurg. 2016 Jul;125(1):85-9. doi: 10.3171/2015.7.JNS151026. Epub 2015 Dec 18.
OBJECT Currently, bilateral procedures involve 2 sequential implants in each of the hemispheres. The present report demonstrates the feasibility of simultaneous bilateral procedures during the implantation of deep brain stimulation (DBS) leads. METHODS Fifty-seven patients with movement disorders underwent bilateral DBS implantation in the same study period. The authors compared the time required for the surgical implantation of deep brain electrodes in 2 randomly assigned groups. One group of 28 patients underwent traditional sequential electrode implantation, and the other 29 patients underwent simultaneous bilateral implantation. Clinical outcomes of the patients with Parkinson's disease (PD) who had undergone DBS implantation of the subthalamic nucleus using either of the 2 techniques were compared. RESULTS Overall, a reduction of 38.51% in total operating time for the simultaneous bilateral group (136.4 ± 20.93 minutes) as compared with that for the traditional consecutive approach (220.3 ± 27.58 minutes) was observed. Regarding clinical outcomes in the PD patients who underwent subthalamic nucleus DBS implantation, comparing the preoperative off-medication condition with the off-medication/on-stimulation condition 1 year after the surgery in both procedure groups, there was a mean 47.8% ± 9.5% improvement in the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score in the simultaneous group, while the sequential group experienced 47.5% ± 15.8% improvement (p = 0.96). Moreover, a marked reduction in the levodopa-equivalent dose from preoperatively to postoperatively was similar in these 2 groups. The simultaneous bilateral procedure presented major advantages over the traditional sequential approach, with a shorter total operating time. CONCLUSIONS A simultaneous stereotactic approach significantly reduces the operation time in bilateral DBS procedures, resulting in decreased microrecording time, contributing to the optimization of functional stereotactic procedures.
目的 目前,双侧手术在每个半球中都涉及 2 个连续的植入物。本报告展示了在深部脑刺激(DBS)导联植入过程中同时进行双侧手术的可行性。
方法 57 例运动障碍患者在同一研究期间接受了双侧 DBS 植入。作者比较了两组随机分配的患者进行深部脑电极植入所需的手术时间。一组 28 例患者接受传统的顺序电极植入,另一组 29 例患者接受双侧同时植入。比较了使用这两种技术进行丘脑底核 DBS 植入的帕金森病(PD)患者的临床结果。
结果 总体而言,与传统的连续方法(220.3 ± 27.58 分钟)相比,双侧同时植入组的总手术时间减少了 38.51%(136.4 ± 20.93 分钟)。在接受丘脑底核 DBS 植入的 PD 患者的临床结果方面,在两组手术中,将术前停药期与术后 1 年停药/刺激期进行比较,在同时组中,帕金森病评定量表第三部分(UPDRS-III)评分平均改善 47.8% ± 9.5%,而序贯组则改善了 47.5% ± 15.8%(p = 0.96)。此外,这两组患者术后左旋多巴等效剂量的显著减少是相似的。与传统的序贯方法相比,同时双侧方法具有明显的优势,总手术时间更短。
结论 立体定向同时方法显著缩短了双侧 DBS 手术的手术时间,减少了微记录时间,有助于优化功能立体定向手术。