Anzak Anam, Tan Huiling, Pogosyan Alek, Khan Sadaquate, Javed Shazia, Gill Steven S, Ashkan Keyoumars, Akram Harith, Foltynie Thomas, Limousin Patricia, Zrinzo Ludvic, Green Alexander L, Aziz Tipu, Brown Peter
Functional Neurosurgery-Experimental Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, OX3 9DU, United Kingdom; Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, United Kingdom.
Functional Neurosurgery-Experimental Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, OX3 9DU, United Kingdom; Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, United Kingdom; Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, OX3 9DU, United Kingdom.
Exp Neurol. 2016 Mar;277:19-26. doi: 10.1016/j.expneurol.2015.12.004. Epub 2015 Dec 11.
Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of 'paradoxical kinesis' in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus - a key component of the reticular activating system - provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an 'energizing' influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease.
在健康受试者中，对强烈刺激会出现运动表现增强的情况，而在帕金森病患者中则表现为“反常运动”。在此，我们在丘脑底核区域的局部场电位记录中识别出一种中潜伏期诱发电位，其振幅与所施加刺激的强度以及最大握力生物力学测量中的相应增强成比例，且与帕金森病受试者的多巴胺能状态无关。在相关的脚桥核（网状激活系统的关键组成部分）中记录到类似的诱发电位，这为丘脑底核中的这种神经特征提供了支持，表明它是从网状激活系统传播而来的一种新的上行唤醒关联，对运动回路施加“激发”影响。未来对这个连接唤醒和运动表现的系统进行操控，可能为帕金森病等运动功能减退疾病患者的运动表现非多巴胺能增强提供一种新方法。
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