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左侧结肠癌的自膨式金属支架(SEMS)——癌症中心的经验

Self-Expanding Metallic Stents (SEMS) in Left-Sided Colonic Cancer--a Cancer Center Experience.

作者信息

Saeed Kamran Muddasar, Zafar Waleed, Masood Muhammad Adnan, Khattak Shahid, Syed Aamir Ali, Yusuf Muhammed Aasim

机构信息

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Punjab, Pakistan.

出版信息

J Gastrointest Cancer. 2016 Mar;47(1):69-74. doi: 10.1007/s12029-015-9789-x.

Abstract

BACKGROUND AND STUDY AIMS

Self-Expanding Metallic Stents (SEMS) are a surgery-sparing option for malignant colonic obstruction. They can be inserted as a "bridge to surgery" (BTS) for potentially curable disease, or as a palliative measure, thereby avoiding the higher morbidity and mortality associated with surgery. The objective of this study was to report our local experience of left-sided colonic stents.

METHODS

Data on 49 patients was collected retrospectively from Oct 2008 to Nov 2014 at our cancer centre. This included demographics, baseline clinical characteristics, indications for SEMS placement (bridge to surgery/palliative), technical and clinical success, complications, and the mean patency of duration. Survival in both groups was also plotted on a Kaplan-Meier chart.

RESULTS

A total of 49 patients with colorectal carcinoma (CRC) of the left side were enrolled. The mean age was 50 years (range 18-86). Ninety percent of patients had disease involving the rectum, sigmoid colon, or both. Forty-seven percent (n = 23) of patients had stent insertion as a BTS, whereas 53% (n = 26) had the procedure with palliative intent. Technical and clinical success rates were 96 and 88%, respectively. The clinical success rate of the palliative arm was lower than that of the BTS arm (p = 0.024). 87.5% (n = 42) had no procedure-related complications. Technical failure, perforation, and stent migration/expulsion, were each observed in 4% of cases. Mean stent patency duration was 83.9 days.

CONCLUSION

SEMS insertion for left-sided malignant colonic obstruction is a safe and effective procedure when used either as a bridge to surgery or with palliative intent.

摘要

背景与研究目的

自膨式金属支架(SEMS)是一种可替代手术治疗恶性结肠梗阻的方法。对于潜在可治愈的疾病,可将其作为“手术桥梁”(BTS)插入,或作为一种姑息性措施,从而避免与手术相关的较高发病率和死亡率。本研究的目的是报告我们在左侧结肠支架置入方面的本地经验。

方法

回顾性收集了2008年10月至2014年11月在我们癌症中心的49例患者的数据。这包括人口统计学、基线临床特征、SEMS置入的指征(手术桥梁/姑息性)、技术和临床成功率、并发症以及平均通畅持续时间。两组的生存率也绘制在Kaplan-Meier图表上。

结果

共纳入49例左侧结直肠癌(CRC)患者。平均年龄为50岁(范围18 - 86岁)。90%的患者疾病累及直肠、乙状结肠或两者。47%(n = 23)的患者将支架置入作为手术桥梁,而53%(n = 26)的患者进行该操作是出于姑息目的。技术成功率和临床成功率分别为96%和88%。姑息组的临床成功率低于手术桥梁组(p = 0.024)。87.5%(n = 42)的患者无手术相关并发症。技术失败、穿孔以及支架迁移/排出在各4%的病例中观察到。平均支架通畅持续时间为83.9天。

结论

对于左侧恶性结肠梗阻,无论是作为手术桥梁还是出于姑息目的,插入SEMS都是一种安全有效的方法。

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