Souza Jeana M E, Chang Marilene R, Brito Daniela Z, Farias Katyuce S, Damasceno-Junior Geraldo A, Turatti Izabel C C, Lopes Norberto P, Santos Edson A, Carollo Carlos A
Laboratório de Produtos Naturais e Espectrometria de Massas, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Laboratório de Pesquisa em Microbiologia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Braz J Microbiol. 2015 Oct-Dec;46(4):1103-10. doi: 10.1590/S1517-838246420131281.
We evaluated the antimicrobial activity of Aspilia latissima - an abundant plant from the Brazilian Pantanal region - against Candida albicans, Candida parapsilosis, Candida krusei, Candida tropicalis, Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli and Staphylococcus aureus. The crude extracts and fractions showed activity in all tested microorganisms. The chloroform fraction of the leaves and roots showed the most antimicrobial activity against S. aureus, with an MIC of 500 μg/mL. This fraction was submitted to bioautographic assays to characterize the activity of the compounds. Two bands from the leaves (L-A and L-B) and three bands from the roots (R-C, R-D and R-E) were bioactive. Within the root-derived bands, the terpene derivatives stigmasterol, kaurenoic acid and kaura-9(11), 16-dien-18-oic acid were identified. Antibiotic activity of A. latissima is reported for the first time.
我们评估了来自巴西潘塔纳尔地区的一种常见植物——宽叶阿斯皮利亚（Aspilia latissima）对白色念珠菌、近平滑念珠菌、克柔念珠菌、热带念珠菌、铜绿假单胞菌、粪肠球菌、大肠杆菌和金黄色葡萄球菌的抗菌活性。粗提物和馏分在所有测试微生物中均表现出活性。叶和根的氯仿馏分对金黄色葡萄球菌表现出最强的抗菌活性，最低抑菌浓度（MIC）为500μg/mL。该馏分进行了生物自显影分析以表征化合物的活性。叶中的两条带（L-A和L-B）和根中的三条带（R-C、R-D和R-E）具有生物活性。在源自根的条带中，鉴定出了萜类衍生物豆甾醇、贝壳杉酸和贝壳杉-9(11),16-二烯-18-酸。首次报道了宽叶阿斯皮利亚的抗生素活性。
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