自组装伤口敷料可抑制基质金属蛋白酶-9并促进糖尿病伤口的体内愈合。
Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo.
作者信息
Castleberry Steven A, Almquist Benjamin D, Li Wei, Reis Tiago, Chow John, Mayner Sarah, Hammond Paula T
机构信息
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
出版信息
Adv Mater. 2016 Mar 2;28(9):1809-17. doi: 10.1002/adma.201503565. Epub 2015 Dec 23.
The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed.
将短干扰RNA（siRNA）直接局部递送至靶组织为目前缺乏有效治疗方法的几种复杂医学病症提供了切实可行的解决方案。本文描述了一种超薄聚合物涂层的开发，该涂层可在体外和体内将siRNA的递送维持长达2周。这项技术成功降低了糖尿病小鼠伤口内基质金属蛋白酶-9（MMP-9）的表达，显著加速了伤口愈合过程并改善了形成组织的质量。
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