恶性疟原虫在人体中的最短红细胞外期周期为6.5天的证据，以及用环子孢子蛋白一个区域的合成肽进行免疫可延缓感染的确认。
Evidence for a 6.5-day minimum exoerythrocytic cycle for Plasmodium falciparum in humans and confirmation that immunization with a synthetic peptide representative of a region of the circumsporozoite protein retards infection.
作者信息
Murphy J R, Baqar S, Davis J R, Herrington D A, Clyde D F
机构信息
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.
出版信息
J Clin Microbiol. 1989 Jul;27(7):1434-7. doi: 10.1128/jcm.27.7.1434-1437.1989.
Abstract
Immunization with a synthetic peptide which is representative of part of the repeating region of Plasmodium falciparum circumsporozoite protein resulted in an immunity which allowed vaccinees to retard the development of patent malaria as compared to nonimmunized controls. Analysis of infection dynamics showed that immunity could be attributed to either neutralization of about 92% of inoculated sporozoites, delayed development of the majority of parasites, or a combination of neutralization and delayed development. In spite of this impressive antiplasmodial capacity, all volunteers after being bitten by infected mosquitoes developed malaria, and seven of eight developed parasitemia between 6.5 and 7.0 days after infective mosquito bites.
摘要
用一种代表恶性疟原虫环子孢子蛋白重复区域部分的合成肽进行免疫接种，产生了一种免疫力，与未免疫的对照组相比，接种疫苗者能够延缓显性疟疾的发展。对感染动态的分析表明，免疫力可归因于对接种的约92%子孢子的中和、大多数寄生虫发育的延迟，或中和与发育延迟的组合。尽管有这种令人印象深刻的抗疟能力，但所有被感染蚊子叮咬的志愿者都患上了疟疾，并且八分之七的人在感染性蚊子叮咬后6.5至7.0天出现了寄生虫血症。
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