热处理对银掺杂生物磷灰石抗菌活性的影响

Influence of Thermal Treatment on the Antimicrobial Activity of Silver-Doped Biological Apatite.

作者信息

Popa Cristina Liana, Ciobanu Carmen Steluta, Voicu Georgeta, Vasile Eugenia, Chifiriuc Mariana Carmen, Iconaru Simona Liliana, Predoi Daniela

机构信息

National Institute of Materials Physics, 105 bis Atomistilor Street, Măgurele, Romania.

Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, 1-7 Polizu Street, Bucharest, Romania.

出版信息

Nanoscale Res Lett. 2015 Dec;10(1):502. doi: 10.1186/s11671-015-1211-x. Epub 2015 Dec 29.

DOI:10.1186/s11671-015-1211-x

PMID:26714864

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4695482/

Abstract

In this paper, we report the structural and morphological properties of silver-doped hydroxyapatite (AgHAp) with a silver concentration x Ag = 0.5 before and after being thermal treated at 600 and 1000 °C. The results obtained by X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy suggest that the structure of the samples changes gradually, from hydroxyapatite (AgHAp_40) to a predominant β-TCP structure (AgHAp_1000), achieved when the thermal treatment temperature is 1000 °C. In the AgHAp_600 sample, the presence of two phases, HAp and β-TCP, was highlighted. Also, scanning electron microscopy studies suggest that the shape and dimension of the nanoparticles begin to change when the temperature increases. The antimicrobial activity of the obtained compounds was evaluated against Klebsiella pneumoniae, Staphylococcus aureus, and Candida albicans strains.

摘要

在本文中，我们报告了银浓度xAg = 0.5的银掺杂羟基磷灰石（AgHAp）在600和1000°C热处理前后的结构和形态特性。通过X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和拉曼光谱获得的结果表明，当热处理温度为1000°C时，样品结构从羟基磷灰石（AgHAp_40）逐渐变化为主导的β-TCP结构（AgHAp_1000）。在AgHAp_600样品中，突出显示了HAp和β-TCP两相的存在。此外，扫描电子显微镜研究表明，当温度升高时，纳米颗粒的形状和尺寸开始发生变化。对所得化合物针对肺炎克雷伯菌、金黄色葡萄球菌和白色念珠菌菌株的抗菌活性进行了评估。