蛛网膜下腔出血大鼠海马模型中对突触序列刺激的氧血流动力学反应失调。
Dysregulation of oxygen hemodynamic responses to synaptic train stimulation in a rat hippocampal model of subarachnoid hemorrhage.
作者信息
Galeffi Francesca, Degan Simone, Britz Gavin, Turner Dennis A
机构信息
Department of Neurosurgery (Surgery), Duke University Medical Center, Durham, NC, USA (Gavin Britz is currently at the Department of Neurosurgery, Houston Methodist Hospital, Houston, TX, USA) Research and Surgery Services, Durham VA Medical Center, Durham, NC, USA.
Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, USA.
出版信息
J Cereb Blood Flow Metab. 2016 Apr;36(4):696-701. doi: 10.1177/0271678X15624699. Epub 2015 Dec 31.
We investigated microvascular reactivity to synaptic train stimulation after induction of subarachnoid hemorrhage in adult rats, analyzing tissue oxygen levels [pO2] in intact hippocampus. In control rats, hippocampal pO2averaged 11.4 mm Hg whereas hemodynamic responses averaged 13.1 mm Hg (to a 25 s train). After subarachnoid hemorrhage (at 2 days), we recorded a dramatic elevation in baseline pO2in the hippocampus (to 68.4 mm Hg) accompanied by inverted pO2responses to synaptic train stimulation (-9.46 mm Hg). These significant changes in baseline hippocampal pO2and inverted pO2responses after subarachnoid hemorrhage indicate severe alterations of neurovascular coupling and neuronal viability.
我们研究了成年大鼠蛛网膜下腔出血诱导后微血管对突触序列刺激的反应性，分析了完整海马体中的组织氧水平[pO2]。在对照大鼠中，海马体pO2平均为11.4毫米汞柱，而血流动力学反应平均为13.1毫米汞柱（对25秒的序列刺激）。蛛网膜下腔出血后（第2天），我们记录到海马体基线pO2显著升高（至68.4毫米汞柱），同时对突触序列刺激的pO2反应倒置（-9.46毫米汞柱）。蛛网膜下腔出血后海马体基线pO2和倒置的pO2反应的这些显著变化表明神经血管耦合和神经元活力发生了严重改变。
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