¹⁸F-氟脱氧葡萄糖正电子发射断层扫描用于评估晚期食管癌新辅助化疗的疗效
¹⁸F-Fluorodeoxyglucose Positron Emission Tomography for Evaluating the Response to Neoadjuvant Chemotherapy in Advanced Esophageal Cancer.
作者信息
Tani Yukiko, Nakajima Masanobu, Kikuchi Maiko, Ihara Keisuke, Muroi Hiroto, Takahashi Masakazu, Domeki Yasushi, Okamoto Kentaro, Yamaguchi Satoru, Sasaki Kinro, Tsuchioka Takashi, Sakamoto Setsu, Kato Hiroyuki
机构信息
First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan
First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
出版信息
Anticancer Res. 2016 Jan;36(1):367-73.
BACKGROUND/AIM: The purpose of the present study was to improve the diagnostic precision of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after neoadjuvant chemotherapy (NAC) in patients with advanced esophageal cancer.
PATIENTS AND METHODS
Thirty patients underwent FDG-PET/CT before and after NAC. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were measured. Patients were divided into two pathological response groups: "responders" (grades 1b-3) or "non-responders" (grades 0-1a).
RESULTS
Overall, 11 patients were responders. Significant differences were present for the post-NAC SUVmax (p=0.070), %decrease in SUVmax (p=0.017), post-NAC MTV (p=0.014), and %decrease in MTV (p=0.003).
CONCLUSION
Receiver operating characteristic curve analysis showed that the %decrease in MTV of the primary tumor was the best indicator of response to NAC. We are currently striving to improve the accuracy of this assessment method.
背景/目的：本研究的目的是提高新辅助化疗（NAC）后18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）对晚期食管癌患者的诊断准确性。
患者与方法
30例患者在NAC前后接受了FDG-PET/CT检查。测量了最大标准化摄取值（SUVmax）和代谢肿瘤体积（MTV）。患者被分为两个病理反应组：“反应者”（1b-3级）或“无反应者”（0-1a级）。
结果
总体而言，11例患者为反应者。NAC后SUVmax（p=0.070）、SUVmax降低百分比（p=0.017）、NAC后MTV（p=0.014）和MTV降低百分比（p=0.003）存在显著差异。
结论
受试者工作特征曲线分析表明，原发肿瘤MTV的降低百分比是对NAC反应的最佳指标。我们目前正在努力提高这种评估方法的准确性。
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