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上颌骨切除术后的功能结局和生活质量:游离血管化皮瓣中种植体支持的阻塞器与种植体支持的固定修复体的比较。

Functional outcome and quality of life after a maxillectomy: a comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap.

作者信息

Wang Feng, Huang Wei, Zhang Chenping, Sun Jian, Qu Xingzhou, Wu Yiqun

机构信息

Department of Oral Implantology, Ninth People's Hospital, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Clin Oral Implants Res. 2017 Feb;28(2):137-143. doi: 10.1111/clr.12771. Epub 2016 Jan 4.

Abstract

OBJECTIVE

Defects of the maxilla caused by tumor resection create high levels of psychological and physical trauma for patients. The application of osseointegrated dental implants using either an obturator prosthesis or a free vascularized flap has tremendously changed the retention and stability of the superstructure. However, no study has been performed to compare the function of the aforementioned two approaches and the quality of life using the subjective assessments of patients.

MATERIALS AND METHODS

Eligible patients who were treated with maxillary resection and rehabilitated with implant supported obturator prostheses (group 1) or those who received free vascularized flap transfers with implant supported fixed prostheses (group 2) were enrolled between March 2006 and May 2014. A questionnaire that included the indices of the Obturator Functioning Scale (OFS), EORTC Head and Neck 35 assessment and the Mental Health Inventory (MHI) was used to evaluate the functional rehabilitation and QOL of patients in the study.

RESULTS

A total of 42 dental implants, including 25 zygomatic implants, were used in 18 patients (mean age: 56.2 ± 12.3 years) in the obturator prostheses in group 1. Twenty patients (mean age: 45.6 ± 14.1 years) who were treated with a vascularized free flap including the fibula (n = 15) and ilium (n = 5) combined with a total of 71 regular implants for fixed prostheses comprised group 2. No statistically significant median differences in the OFS, EORTC Head and Neck assessment and MHI global scale were observed between the groups. On the MHI subscales item-levels, higher median subscale scores exhibited by group 1 than group 2 and had statistically significant difference between the groups (P = 0.024).

CONCLUSION

Within the limitations of this study, it demonstrated no difference in oral function between patients with implant supported obturators and implant supported fixed prostheses in free vascularized flaps after a maxillectomy. However, patients who received obturator therapy seemed to have poorer mental health than did patients with fixed prostheses, but it should be interpreted prudently with the study's limitation.

摘要

目的

肿瘤切除导致的上颌骨缺损给患者带来了极大的心理和身体创伤。使用阻塞器假体或游离血管化皮瓣的骨结合牙种植体的应用极大地改变了上部结构的固位和稳定性。然而,尚未有研究通过患者的主观评估来比较上述两种方法的功能及生活质量。

材料与方法

选取2006年3月至2014年5月期间接受上颌骨切除并采用种植体支持的阻塞器假体修复的符合条件的患者(第1组),以及接受游离血管化皮瓣转移并采用种植体支持的固定假体修复的患者(第2组)。使用一份包含阻塞器功能量表(OFS)指标、欧洲癌症研究与治疗组织(EORTC)头颈35项评估和心理健康量表(MHI)的问卷来评估研究中患者的功能康复情况和生活质量。

结果

第1组中,18例患者(平均年龄:56.2±12.3岁)使用了共42颗牙种植体,其中包括25颗颧骨种植体。第2组有20例患者(平均年龄:45.6±14.1岁)接受了包括腓骨(n = 15)和髂骨(n = 5)的游离血管化皮瓣治疗,并使用了共71颗常规种植体用于固定假体修复。两组在OFS、EORTC头颈评估和MHI总体量表方面未观察到统计学上的显著中位数差异。在MHI子量表项目水平上,第1组的中位数子量表得分高于第2组,且两组之间存在统计学上的显著差异(P = 0.024)。

结论

在本研究的局限性范围内,结果表明上颌骨切除术后,种植体支持的阻塞器患者与游离血管化皮瓣中种植体支持的固定假体患者在口腔功能方面无差异。然而,接受阻塞器治疗的患者心理健康状况似乎比接受固定假体的患者差,但鉴于本研究的局限性,对此应谨慎解读。

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