通过铑（III）催化的脱氢C-H/N-H官能化合成噌啉：聚集诱导发光及细胞成像
Synthesis of cinnolines via Rh(iii)-catalysed dehydrogenative C-H/N-H functionalization: aggregation induced emission and cell imaging.
作者信息
Mayakrishnan Sivakalai, Arun Yuvaraj, Balachandran Chandrasekar, Emi Nobuhiko, Muralidharan Doraiswamy, Perumal Paramasivan Thirumalai
机构信息
Organic & Bioorganic Chemistry, Council of Scientific and Industrial Research (CSIR)-CLRI, Chennai, 600020, India.
Department of Hematology, Fujita Health University, Aichi 470-1192, Japan.
出版信息
Org Biomol Chem. 2016 Feb 14;14(6):1958-68. doi: 10.1039/c5ob02045j.
Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.
通过铑催化的脱氢C-H/N-H官能团化反应，使N-苯基酞嗪/吲唑与炔烃反应，构建了酞嗪并[2,3-a]-/吲唑并[1,2-a]噌啉。合成的化合物在固态和聚集态下表现出显著的荧光特性。使用多种癌细胞系研究了它们在细胞成像中的应用。
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