Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India.
Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India.
Eur J Med Chem. 2016 Feb 15;109:89-98. doi: 10.1016/j.ejmech.2015.12.022. Epub 2015 Dec 23.
The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with 2-AT core are in the market, e.g. Famotidine, Cefdinir, Meloxcam etc. Recently, 2-AT core has been explored for many more important therapeutic areas and identified new 2-aminothiazoles with anticancer, antitumor, antidiebatic and anticonvulsant activity. In this review, we discuss the newly identified and developed 2-aminothiazoles in recent years and their use in medicinal chemistry and pharmacology.
2-氨基噻唑（2-AT）核心是一种活性药效团，用于医学化学和药物发现研究。许多含有 2-AT 核心的药物已经上市，例如法莫替丁、头孢地尼、美洛昔康等。最近，2-AT 核心已被探索用于更多重要的治疗领域，并发现了具有抗癌、抗肿瘤、抗糖尿病和抗惊厥活性的新型 2-氨基噻唑。在这篇综述中，我们讨论了近年来新发现和开发的 2-氨基噻唑及其在药物化学和药理学中的应用。
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