Bremmer F, Schweyer S
Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Deutschland.
Gemeinschaftspraxis Pathologie Starnberg, Am Fuchsengraben 3, 82319, Starnberg, Deutschland.
Pathologe. 2016 Feb;37(1):71-7. doi: 10.1007/s00292-015-0131-y.
According to the World Health Organization (WHO) classification Leydig cell tumors, Sertoli cell tumors and granulosa cell tumors of the testes belong to the group of sex cord-stromal tumors. These tumors most frequently occur sporadically but in rare cases can be associated with syndromes. These tumor entities show characteristic morphological changes, which in combination with specific immunohistochemical markers facilitate the diagnosis. Recent results of molecular pathological investigations, especially beta-catenin mutation analysis, allow a better categorization of these tumor entities.
根据世界卫生组织(WHO)的分类,睾丸间质细胞瘤、支持细胞瘤和颗粒细胞瘤属于性索间质肿瘤组。这些肿瘤最常散发性发生,但在罕见情况下可能与综合征相关。这些肿瘤实体呈现出特征性的形态学变化,结合特定的免疫组化标记有助于诊断。分子病理学研究的最新结果,尤其是β-连环蛋白突变分析,使这些肿瘤实体能够得到更好的分类。