p75神经营养因子受体的裂解与阿尔茨海默病有关。 - Suppr

Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.

作者信息

Chao M V

机构信息

Departments of Cell Biology, Physiology and Neuroscience and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University Langone School of Medicine, New York, NY, USA.

出版信息

Mol Psychiatry. 2016 Mar;21(3):300-1. doi: 10.1038/mp.2015.214. Epub 2016 Jan 19.

DOI:10.1038/mp.2015.214

PMID:26782055

Abstract

摘要

相似文献

Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.

Mol Psychiatry. 2016 Mar;21(3):300-1. doi: 10.1038/mp.2015.214. Epub 2016 Jan 19.

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease.

Mol Psychiatry. 2015 Nov;20(11):1301-10. doi: 10.1038/mp.2015.49. Epub 2015 Apr 28.

Alzheimer's therapeutics: neurotrophin domain small molecule mimetics.

J Mol Neurosci. 2003;20(3):323-6. doi: 10.1385/JMN:20:3:323.

Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.

J Neurosci Res. 2004 Oct 15;78(2):186-92. doi: 10.1002/jnr.20262.

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.

Science. 2004 May 7;304(5672):870-5. doi: 10.1126/science.1095190.

Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):352-6. doi: 10.1016/j.bbrc.2009.09.116. Epub 2009 Oct 7.

Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.

Neurobiol Aging. 2015 Feb;36(2):740-52. doi: 10.1016/j.neurobiolaging.2014.09.014. Epub 2014 Sep 28.

Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients.

Neurochem Int. 2016 Dec;101:22-29. doi: 10.1016/j.neuint.2016.09.015. Epub 2016 Sep 29.

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.

Neurobiol Dis. 2005 Dec;20(3):969-85. doi: 10.1016/j.nbd.2005.06.004. Epub 2005 Jul 11.

Dimerization-dependent block of the proapoptotic effect of p75(NTR).

J Neurosci Res. 2000 Jun 1;60(5):587-93. doi: 10.1002/(SICI)1097-4547(20000601)60:5<587::AID-JNR3>3.0.CO;2-1.

引用本文的文献

Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain.

Neural Regen Res. 2022 Apr;17(4):701-704. doi: 10.4103/1673-5374.314291.

Neurotrophin Receptor p75 mRNA Level in Peripheral Blood Cells of Patients with Alzheimer's Disease.

Neurotox Res. 2019 Jul;36(1):101-107. doi: 10.1007/s12640-019-00035-9. Epub 2019 Apr 11.

proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing.

Mol Brain. 2018 Nov 14;11(1):68. doi: 10.1186/s13041-018-0411-6.

Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.

Mol Neurobiol. 2019 Feb;56(2):812-830. doi: 10.1007/s12035-018-1106-9. Epub 2018 May 24.

本文引用的文献

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease.

Mol Psychiatry. 2015 Nov;20(11):1301-10. doi: 10.1038/mp.2015.49. Epub 2015 Apr 28.

Neuron-type-specific signaling by the p75NTR death receptor is regulated by differential proteolytic cleavage.

J Cell Sci. 2015 Apr 15;128(8):1507-17. doi: 10.1242/jcs.161745. Epub 2015 Feb 26.

Deciphering proneurotrophin actions.

Handb Exp Pharmacol. 2014;220:17-32. doi: 10.1007/978-3-642-45106-5_2.

Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis.

Mol Neurobiol. 2012 Dec;46(3):588-604. doi: 10.1007/s12035-012-8310-9. Epub 2012 Sep 1.

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity.

Trends Neurosci. 2012 Jul;35(7):431-40. doi: 10.1016/j.tins.2012.03.007. Epub 2012 Apr 13.

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

Sci Signal. 2011 Dec 6;4(202):ra82. doi: 10.1126/scisignal.2002060.

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

J Neurosci. 2011 Feb 9;31(6):2292-304. doi: 10.1523/JNEUROSCI.2733-10.2011.

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.

J Biol Chem. 2005 Apr 15;280(15):14563-71. doi: 10.1074/jbc.M412957200. Epub 2005 Feb 8.

Neurotrophins and their receptors: a convergence point for many signalling pathways.

Nat Rev Neurosci. 2003 Apr;4(4):299-309. doi: 10.1038/nrn1078.

P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.

Nature. 2002 Nov 7;420(6911):74-8. doi: 10.1038/nature01176. Epub 2002 Oct 20.

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Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.

作者信息

Chao M V

机构信息

Departments of Cell Biology, Physiology and Neuroscience and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University Langone School of Medicine, New York, NY, USA.

出版信息

Mol Psychiatry. 2016 Mar;21(3):300-1. doi: 10.1038/mp.2015.214. Epub 2016 Jan 19.

DOI:10.1038/mp.2015.214

PMID:26782055

Abstract

摘要

相似文献

Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.

Mol Psychiatry. 2016 Mar;21(3):300-1. doi: 10.1038/mp.2015.214. Epub 2016 Jan 19.

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease.

Mol Psychiatry. 2015 Nov;20(11):1301-10. doi: 10.1038/mp.2015.49. Epub 2015 Apr 28.

Alzheimer's therapeutics: neurotrophin domain small molecule mimetics.

J Mol Neurosci. 2003;20(3):323-6. doi: 10.1385/JMN:20:3:323.

Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.

J Neurosci Res. 2004 Oct 15;78(2):186-92. doi: 10.1002/jnr.20262.

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.

Science. 2004 May 7;304(5672):870-5. doi: 10.1126/science.1095190.

Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):352-6. doi: 10.1016/j.bbrc.2009.09.116. Epub 2009 Oct 7.

Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.

Neurobiol Aging. 2015 Feb;36(2):740-52. doi: 10.1016/j.neurobiolaging.2014.09.014. Epub 2014 Sep 28.

Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients.

Neurochem Int. 2016 Dec;101:22-29. doi: 10.1016/j.neuint.2016.09.015. Epub 2016 Sep 29.

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.

Neurobiol Dis. 2005 Dec;20(3):969-85. doi: 10.1016/j.nbd.2005.06.004. Epub 2005 Jul 11.

Dimerization-dependent block of the proapoptotic effect of p75(NTR).

J Neurosci Res. 2000 Jun 1;60(5):587-93. doi: 10.1002/(SICI)1097-4547(20000601)60:5<587::AID-JNR3>3.0.CO;2-1.

引用本文的文献

Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain.

Neural Regen Res. 2022 Apr;17(4):701-704. doi: 10.4103/1673-5374.314291.

Neurotrophin Receptor p75 mRNA Level in Peripheral Blood Cells of Patients with Alzheimer's Disease.

Neurotox Res. 2019 Jul;36(1):101-107. doi: 10.1007/s12640-019-00035-9. Epub 2019 Apr 11.

proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing.

Mol Brain. 2018 Nov 14;11(1):68. doi: 10.1186/s13041-018-0411-6.

Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.

Mol Neurobiol. 2019 Feb;56(2):812-830. doi: 10.1007/s12035-018-1106-9. Epub 2018 May 24.

本文引用的文献

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease.

Mol Psychiatry. 2015 Nov;20(11):1301-10. doi: 10.1038/mp.2015.49. Epub 2015 Apr 28.

Neuron-type-specific signaling by the p75NTR death receptor is regulated by differential proteolytic cleavage.

J Cell Sci. 2015 Apr 15;128(8):1507-17. doi: 10.1242/jcs.161745. Epub 2015 Feb 26.

Deciphering proneurotrophin actions.

Handb Exp Pharmacol. 2014;220:17-32. doi: 10.1007/978-3-642-45106-5_2.

Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis.

Mol Neurobiol. 2012 Dec;46(3):588-604. doi: 10.1007/s12035-012-8310-9. Epub 2012 Sep 1.

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity.

Trends Neurosci. 2012 Jul;35(7):431-40. doi: 10.1016/j.tins.2012.03.007. Epub 2012 Apr 13.

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

Sci Signal. 2011 Dec 6;4(202):ra82. doi: 10.1126/scisignal.2002060.

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

J Neurosci. 2011 Feb 9;31(6):2292-304. doi: 10.1523/JNEUROSCI.2733-10.2011.

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.

J Biol Chem. 2005 Apr 15;280(15):14563-71. doi: 10.1074/jbc.M412957200. Epub 2005 Feb 8.

Neurotrophins and their receptors: a convergence point for many signalling pathways.

Nat Rev Neurosci. 2003 Apr;4(4):299-309. doi: 10.1038/nrn1078.

P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.

Nature. 2002 Nov 7;420(6911):74-8. doi: 10.1038/nature01176. Epub 2002 Oct 20.

Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.

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Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.

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