Farzaei Mohammad Hosein, Bahramsoltani Roodabeh, Abdolghaffari Amir Hossein, Sodagari Hamid Reza, Esfahani Shadi A, Rezaei Nima
a Pharmaceutical Sciences Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.
b Medical Biology Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.
Expert Rev Gastroenterol Hepatol. 2016 Jun;10(6):745-58. doi: 10.1586/17474124.2016.1145546. Epub 2016 Feb 20.
Inflammatory bowel disease (IBD) is a recurrent idiopathic inflammatory condition, characterized by disruption of the gut mucosal barrier. This mechanistic review aims to highlight the significance of plant-derived natural compounds as dietary supplements, which can be used in addition to restricted conventional options for the prevention of IBD and induction of remission. Various clinical trials confirmed the effectiveness and tolerability of natural supplements in patients with IBD. Mounting evidence suggests that these natural compounds perform their protective and therapeutic effect on IBD through numerous molecular mechanisms, including anti-inflammatory and immunoregulatory, anti-oxidative stress, modulation of intracellular signaling transduction pathways, as well as improving gut microbiota. In conclusion, natural products can be considered as dietary supplements with therapeutic potential for IBD, provided that their safety and efficacy is confirmed in future well-designed clinical trials with adequate sample size.
炎症性肠病（IBD）是一种复发性特发性炎症性疾病，其特征是肠道黏膜屏障破坏。本机制综述旨在强调植物源天然化合物作为膳食补充剂的重要性，这些化合物除了可用于预防IBD和诱导缓解的有限传统选择外，还可使用。各种临床试验证实了天然补充剂对IBD患者的有效性和耐受性。越来越多的证据表明，这些天然化合物通过多种分子机制对IBD发挥保护和治疗作用，包括抗炎和免疫调节、抗氧化应激、调节细胞内信号转导通路以及改善肠道微生物群。总之，天然产物可被视为具有IBD治疗潜力的膳食补充剂，前提是其安全性和有效性在未来设计良好、样本量充足的临床试验中得到证实。
