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[口面部疼痛 - 三叉神经痛和创伤后三叉神经病变:共同特征与差异]

[Orofacial pain - Trigeminal neuralgia and posttraumatic trigeminal neuropathy: Common features and differences].

作者信息

Thieme V

机构信息

Sternklinik Bremen, Praxis für MKG-Chirurgie, Carl-Ronning-Str. 4-6, 28195, Bremen, Deutschland.

出版信息

Schmerz. 2016 Feb;30(1):99-117. doi: 10.1007/s00482-016-0097-6.

Abstract

Neuropathic pain is the result of a lesion or disease of the somatosensory system in the peripheral or central nervous system. Classical trigeminal neuralgia and posttraumatic trigeminal neuropathy are pain disorders which oral and maxillofacial surgeons and dentists are confronted with in the differential diagnostics in routine daily practice. The etiopathogenesis of classical trigeminal neuralgia is attributable to pathological blood vessel-nerve contact in the trigeminal nerve root entry zone to the brain stem. The typical pain symptoms are characterized by sudden stabbing pain attacks. The pharmaceutical prophylaxis is based on the individually titrated administration of anticonvulsant drugs. The indications for interventional treatment are dependent on the course, response to drug treatment, resilience and wishes of the patient. The neuropathic mechanism of posttraumatic trigeminal neuropathy originates from nerve damage, which leads to peripheral and central sensitization with lowering of the pain threshold and multiple somatosensory disorders. The prophylaxis consists of avoidance of excessive acute and long-lasting pain stimuli. Against the background of the biopsychosocial pain model, the treatment of posttraumatic trigeminal neuropathy necessitates a multimodal, interdisciplinary concept.

摘要

神经性疼痛是外周或中枢神经系统中躯体感觉系统发生病变或疾病的结果。典型的三叉神经痛和创伤后三叉神经病变是口腔颌面外科医生和牙医在日常常规鉴别诊断中会遇到的疼痛病症。典型三叉神经痛的病因发病机制可归因于三叉神经根进入脑干区域的病理性血管 - 神经接触。典型的疼痛症状表现为突发的刺痛发作。药物预防基于抗惊厥药物的个体化滴定给药。介入治疗的指征取决于病程、对药物治疗的反应、患者的耐受性和意愿。创伤后三叉神经病变的神经病理机制源于神经损伤,这会导致外周和中枢敏化,伴有痛阈降低和多种躯体感觉障碍。预防措施包括避免过度的急性和长期疼痛刺激。在生物心理社会疼痛模型的背景下,创伤后三叉神经病变的治疗需要一个多模式、跨学科的概念。

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