Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA.
作者信息
Han Xiongqi, Chen Qixian, Lu Hongguang, Guo Pan, Li Wei, Wu Guolin, Ma Jianbiao, Gao Hui
机构信息
School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, China.
出版信息
Chem Commun (Camb). 2016 Mar 11;52(20):3907-10. doi: 10.1039/c5cc09836j. Epub 2016 Jan 27.
PMID:26816096
Abstract
A fluorophore displaying aggregation-induced emission was introduced at the terminus of branched polyethylenimine (PEI). The formulated polyplex not only demonstrated an improved safety profile and preserved transfection activity but also importantly indicated that the uncomplexed naked DNA rather than the polyplexes translocated into the nucleus.
摘要
Zotero 插件