Pergam Steven A
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, E4-100, Seattle, WA, 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, E4-100, Seattle, WA, 98109, USA.
Curr Infect Dis Rep. 2016 Jan;18(2):7. doi: 10.1007/s11908-015-0513-6.
The number of patients undergoing hematopoietic cell and solid organ transplantation are increasing every year, as are the number of centers both transplanting and caring for these patients. Improvements in transplant procedures, immunosuppressive regimens, and prevention of transplant-associated complications have led to marked improvements in survival in both populations. Infections remain one of the most important sources of excess morbidity and mortality in transplant, and therefore, infection prevention strategies are a critical element for avoiding these complications in centers caring for high-risk patients. This manuscript aims to provide an update of recent data on prevention of major healthcare-associated infections unique to transplantation, reviews the emergence of antimicrobial resistant infections, and discusses updated strategies to both identify and prevent transmission of these pathogens in transplant recipients.
接受造血细胞移植和实体器官移植的患者数量每年都在增加,进行移植及照料这些患者的中心数量也在增加。移植程序、免疫抑制方案以及移植相关并发症预防措施的改进,使这两类患者群体的生存率都有了显著提高。感染仍然是移植患者额外发病和死亡的最重要来源之一,因此,感染预防策略是在照料高危患者的中心避免这些并发症的关键要素。本手稿旨在提供有关移植特有的主要医疗保健相关感染预防的最新数据,回顾抗菌药物耐药性感染的出现情况,并讨论识别和预防这些病原体在移植受者中传播的最新策略。