[四川省绵阳市乙肝表面抗原和乙肝表面抗体均为阴性的成年人分布情况]
[Distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province].
作者信息
Cheng Shuwen, Xiao Chuan, Wang Min, Wang Lan, Wang Juan, Ren Tao, Wang Liping, Wen Xiaohua, Zhang Wenhao, Yuan Ping
机构信息
West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
Respiratory and Critical Care Department, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Jan;37(1):60-3. doi: 10.3760/cma.j.issn.0254-6450.2016.01.012.
OBJECTIVE
To understand the distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province, and provide evidences for the development of adult immunization policy.
METHODS
From June 2013 to April 2014, a total of 200 929 people aged ≥15 years were selected in Mianyang through stratified cluster random sampling to conduct an interview with standard questionnaire. The blood samples were collected from them for the detection of HBsAg and HBsAb with enzyme-linked immunosorbent assay (ELISA).
RESULTS
Among the people surveyed, 13 903 were HBsAg positive (7.0%), 93 763 were HBsAb positive (46.6%), and 93 122 were both HBsAg and HBsAb negative (46.3%). The negative rate of both HBsAg and HBsAb in females (47.1%) was higher than that in males (45.4%). The negative rate of both HBsAg and HBsAb increased with age. The negative rate of both HBsAg and HBsAb was highest in people aged ≥65 years (50.3%) and lowest in people aged 15-24 years (42.9%). The negative rate of both HBsAg and HBsAb was highest in farmers (51.1%) and lowest in medical workers (24.1%). The negative rate of both HBsAg and HBsAb was highest in the widowed (51.1%) and lowest in the unmarried (41.6%). The negative rate of both HBsAg and HBsAb was lower in people with family history of hepatitis B (36.5%) than in people without family history of hepatitis B (46.6%). The negative rate of both HBsAg and HBsAb in Han ethnic group was lower (46.3%) than that in Qiang ethnic group (53.1%), but higher than that in other ethnic groups (43.9%). The negative rate of both HBsAg and HBsAb was higher in rural area (48.9%) than in urban area (43.0%). The negative rate of both HBsAg and HBsAb was lower in people who had received hepatitis B immunization (43.7%) than in people who had received no hepatitis B immunization (47.3%). The differences were all statistical significant (P<0.01).
CONCLUSION
The negative rate of both HBsAg and HBsAb was 46.3% in people aged ≥15 years in Mianyang. General population are susceptible to hepatitis B virus infection. It is necessary to develop and implement appropriate hepatitis B immunization strategy for local adult population.
目的
了解四川省绵阳市15岁及以上成人乙肝表面抗原（HBsAg）和乙肝表面抗体（HBsAb）双阴性人群的分布情况，为制定成人免疫策略提供依据。
方法
2013年6月至2014年4月，通过分层整群随机抽样在绵阳市选取200 929名15岁及以上人群，采用标准化问卷进行访谈，并采集血样，采用酶联免疫吸附试验（ELISA）检测HBsAg和HBsAb。
结果
在调查人群中，HBsAg阳性13 903人（7.0%），HBsAb阳性93 763人（46.6%），HBsAg和HBsAb双阴性93 122人（46.3%）。女性HBsAg和HBsAb双阴性率（47.1%）高于男性（45.4%）。HBsAg和HBsAb双阴性率随年龄增长而升高，65岁及以上人群最高（50.3%），15 - 24岁人群最低（42.9%）。农民HBsAg和HBsAb双阴性率最高（51.1%），医务人员最低（24.1%）。丧偶人群HBsAg和HBsAb双阴性率最高（51.1%），未婚人群最低（41.6%）。有乙肝家族史人群的HBsAg和HBsAb双阴性率（36.5%）低于无乙肝家族史人群（46.6%）。汉族人群HBsAg和HBsAb双阴性率（46.3%）低于羌族（53.1%），但高于其他民族（43.9%）。农村地区HBsAg和HBsAb双阴性率（48.9%）高于城市地区（43.0%）。接种过乙肝疫苗人群的HBsAg和HBsAb双阴性率（43.7%）低于未接种过乙肝疫苗人群（47.3%）。差异均有统计学意义（P<0.01）。
结论
绵阳市15岁及以上人群HBsAg和HBsAb双阴性率为46.3%，普通人群对乙肝病毒感染易感，有必要针对当地成年人群制定并实施合适的乙肝免疫策略。
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