从雷公藤中分离出的真菌内生菌——特异青霉lgt-4中得到的一种新呋喃甾体。
A new furanosteroid from Talaromyces sp. lgt-4, a fungal endophyte isolated from Tripterygium wilfordii.
作者信息
Zhi Kang-Kang, Yang Zhong-Duo, Zhou Shuang-Yan, Yao Xiao-Jun, Li Shuo, Zhang Fei
机构信息
a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
b The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
出版信息
Nat Prod Res. 2016 Oct;30(19):2137-41. doi: 10.1080/14786419.2016.1138301. Epub 2016 Feb 1.
Wortmannolol (1), a new furanosteroid, along with five known compounds, wortmannolone (2), ergosterol (3), p-hydroxyphenyl ethanol (4), trans-6-dodecene (5), (2Z, 4E) -5-(8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo [3.2.1] octan-8-yl) -3-methylpenta-2,4-dienoic acid (6) were isolated from a fungal endophyte Talaromyces sp. lgt-4. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. Compound 1 show weak monoamine oxidase inhibitory activity.
渥曼诺洛尔（1），一种新的呋喃甾醇，与五种已知化合物，渥曼诺龙（2）、麦角甾醇（3）、对羟基苯乙醇（4）、反式-6-十二碳烯（5）、(2Z, 4E)-5-(8-羟基-1,5-二甲基-3-氧代-6-氧杂双环[3.2.1]辛烷-8-基)-3-甲基戊-2,4-二烯酸（6）一起，从真菌内生菌特异青霉属菌株lgt-4中分离得到。通过红外光谱、质谱、一维和二维核磁共振光谱对它们的结构进行了阐明。化合物1显示出较弱的单胺氧化酶抑制活性。
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