Mattila Pieta K, Batista Facundo D, Treanor Bebhinn
Institute of Biomedicine, MediCity, University of Turku, 20520 Turku, Finland.
Lymphocyte Interaction Laboratory, The Francis Crick Institute, Cancer Research UK, London WC2A 3LY, England, UK.
J Cell Biol. 2016 Feb 1;212(3):267-80. doi: 10.1083/jcb.201504137.
Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival.
最近的证据表明，肌动蛋白细胞骨架参与受体信号传导的调控。在免疫受体（如B细胞受体）的背景下，这可能尤为重要，因为信号传导失调会导致自身免疫和恶性肿瘤。在这里，我们讨论肌动蛋白细胞骨架在控制受体分隔、动力学和聚集方面的作用，以此作为通过控制与蛋白质伴侣的相互作用来调节受体信号传导的一种手段。我们提出，肌动蛋白细胞骨架是通过调节蛋白质动力学和聚集来实现受体相互作用的整合点。我们讨论了这种通过细胞骨架的相互作用对于免疫细胞存活所必需的配体诱导信号和低水平组成性（张力性）信号的意义。
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