Shah Ashok, Gera Kamal, Panjabi Chandramani
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110 007, India.
Asia Pac Allergy. 2016 Jan;6(1):67-9. doi: 10.5415/apallergy.2016.6.1.67. Epub 2016 Jan 27.
Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral view confirmed a MLS, which was further corroborated by high resolution computed tomography. Central bronchiectasis was also observed, which prompted a work-up for ABPA. The child met 7/8 major diagnostic criteria for ABPA. She was then initiated on oral prednisolone that resulted in a marked clinical improvement within a fortnight. Radiological clearance occurred at 3 months with inflation of the middle lobe. ABPA presenting with MLS in a child is yet to be reported. A high index of suspicion is required to establish the diagnosis of ABPA in a child presenting with MLS. This would obviate the invasive investigations usually done to ascertain the cause of MLS.
变应性支气管肺曲霉菌病(ABPA)在哮喘儿童中鲜有记录。虽然肺不张并不罕见,但作为ABPA表现形式的中叶综合征(MLS)却相当少见。一名9岁哮喘女童症状加重,胸部X线片显示右肺中区有斑片状实变。此外,还注意到右心缘旁有边界不清的致密影,心脏轮廓消失。右侧位片证实为MLS,高分辨率计算机断层扫描进一步证实。还观察到中央型支气管扩张,这促使对ABPA进行检查。该患儿符合ABPA的7/8项主要诊断标准。随后她开始口服泼尼松龙,两周内临床症状明显改善。3个月时中叶充气,影像学上病变消散。儿童ABPA表现为MLS的情况尚未见报道。对于出现MLS的儿童,需要高度怀疑才能诊断ABPA。这将避免通常为确定MLS病因所做的侵入性检查。