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表现为中叶综合征的儿童过敏性支气管肺曲霉病。

Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome.

作者信息

Shah Ashok, Gera Kamal, Panjabi Chandramani

机构信息

Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110 007, India.

出版信息

Asia Pac Allergy. 2016 Jan;6(1):67-9. doi: 10.5415/apallergy.2016.6.1.67. Epub 2016 Jan 27.

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral view confirmed a MLS, which was further corroborated by high resolution computed tomography. Central bronchiectasis was also observed, which prompted a work-up for ABPA. The child met 7/8 major diagnostic criteria for ABPA. She was then initiated on oral prednisolone that resulted in a marked clinical improvement within a fortnight. Radiological clearance occurred at 3 months with inflation of the middle lobe. ABPA presenting with MLS in a child is yet to be reported. A high index of suspicion is required to establish the diagnosis of ABPA in a child presenting with MLS. This would obviate the invasive investigations usually done to ascertain the cause of MLS.

摘要

变应性支气管肺曲霉菌病(ABPA)在哮喘儿童中鲜有记录。虽然肺不张并不罕见,但作为ABPA表现形式的中叶综合征(MLS)却相当少见。一名9岁哮喘女童症状加重,胸部X线片显示右肺中区有斑片状实变。此外,还注意到右心缘旁有边界不清的致密影,心脏轮廓消失。右侧位片证实为MLS,高分辨率计算机断层扫描进一步证实。还观察到中央型支气管扩张,这促使对ABPA进行检查。该患儿符合ABPA的7/8项主要诊断标准。随后她开始口服泼尼松龙,两周内临床症状明显改善。3个月时中叶充气,影像学上病变消散。儿童ABPA表现为MLS的情况尚未见报道。对于出现MLS的儿童,需要高度怀疑才能诊断ABPA。这将避免通常为确定MLS病因所做的侵入性检查。

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