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累及根部的急性主动脉夹层:根治性近端修复术后的手术及长期结果。

Acute aortic dissection involving the root: operative and long-term outcome after curative proximal repair.

作者信息

Urbanski Paul P, Lenos Aristidis, Irimie Vadim, Bougioukakis Petros, Zacher Michael, Diegeler Anno

机构信息

Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany

Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany.

出版信息

Interact Cardiovasc Thorac Surg. 2016 May;22(5):620-6. doi: 10.1093/icvts/ivw002. Epub 2016 Feb 3.

Abstract

OBJECTIVES

The aim of the study was to evaluate operative and long-term results after surgery of acute aortic dissection involving the root, in which the proximal repair consisted of curative resection of all dissected aortic sinuses and was performed using either valve-sparing root repair or complete root replacement with a valve conduit.

METHODS

Between August 2002 and March 2013, 162 consecutive patients (mean age 63 ± 14 years) underwent surgery for acute type A aortic dissection. Eighty-six patients with an involvement of the aortic root underwent curative surgery of the proximal aorta consisting of valve-sparing root repair (n = 54, 62.8%) or complete valve and root replacement using composite valve grafts (n = 32, 37.2%). In patients with root repair, all dissected aortic walls were resected and root remodelling using the single patch technique (n = 53) or root repair with valve reimplantation (n = 1) was performed without the use of any glue. All perioperative data were collected prospectively and retrospective statistical examination was performed using univariate and multivariate analyses.

RESULTS

The mean follow-up was 5.2 ± 3.5 years for all patients (range 0-12 years) and 6.1 ± 3.3 years for survivors. The 30-day mortality rate was 5.8% (5 patients), being considerably lower in the repair sub-cohort (1.9 vs 12.5%). The estimated survival rate at 5 and 10 years was 80.0 ± 4.5 and 69.1 ± 6.7%, respectively. No patient required reoperation on the proximal aorta and/or aortic valve during the follow-up time and there were only two valve-related events (both embolic, one in each group). Among those patients with repaired valves, the last echocardiography available showed no insufficiency in 40 and an irrelevant insufficiency (1+) in 14.

CONCLUSIONS

Curative repair of the proximal aorta in acute dissection involving the root provides favourable operative and long-term outcome with very low risk of aortic complications and/or reoperations, regardless if a valve-sparing procedure or replacement with a valve conduit is used. Valve-sparing surgery is frequently suitable, providing excellent outcome and very high durability.

摘要

目的

本研究旨在评估累及主动脉根部的急性主动脉夹层手术后的手术效果和长期预后,其中近端修复包括对所有夹层主动脉窦进行根治性切除,并采用保留瓣膜的根部修复术或使用带瓣管道进行完全根部置换术。

方法

2002年8月至2013年3月期间,162例连续患者(平均年龄63±14岁)接受了急性A型主动脉夹层手术。86例主动脉根部受累患者接受了近端主动脉根治性手术,包括保留瓣膜的根部修复术(n = 54,62.8%)或使用复合带瓣移植物进行完全瓣膜和根部置换术(n = 32,37.2%)。在根部修复的患者中,所有夹层主动脉壁均被切除,并采用单片技术进行根部重塑(n = 53)或进行瓣膜再植入的根部修复术(n = 1),均未使用任何胶水。所有围手术期数据均前瞻性收集,并采用单因素和多因素分析进行回顾性统计检验。

结果

所有患者的平均随访时间为5.2±3.5年(范围0 - 12年),幸存者的平均随访时间为6.1±3.3年。30天死亡率为5.8%(5例患者),修复亚组的死亡率显著更低(1.9%对12.5%)。5年和10年的估计生存率分别为80.0±4.5%和69.1±6.7%。随访期间,无患者需要对近端主动脉和/或主动脉瓣进行再次手术,仅有两例瓣膜相关事件(均为栓塞事件,每组各1例)。在接受瓣膜修复的患者中,最后一次可用的超声心动图显示,40例患者无反流,14例患者有轻度反流(1+)。

结论

对于累及根部的急性夹层,近端主动脉的根治性修复提供了良好的手术和长期预后,主动脉并发症和/或再次手术的风险极低,无论采用保留瓣膜手术还是使用带瓣管道进行置换。保留瓣膜手术通常是合适的,可提供优异的预后和极高的耐用性。

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