Comenius University in Bratislava, Faculty of Natural Sciences, Department of Microbiology & Virology, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovak Republic.
Future Microbiol. 2016;11(2):235-51. doi: 10.2217/fmb.15.139. Epub 2016 Feb 5.
Biofilms formed by Candida species (spp.) on medical devices represent a potential health risk. The focus of current research is searching for new options for the treatment and prevention of biofilm-associated infections using different approaches including modern nanotechnology. This review summarizes current information concerning the most relevant resistance/tolerance mechanisms to conventional drugs and a role of additional factors contributing to these phenomena in Candida spp. (mostly Candida albicans). Additionally, it provides an information update in prevention and eradication of a Candida biofilm including experiences with 'lock' therapy, potential utilization of small molecules in biomedical applications, and perspectives of using photodynamic inactivation in the control of a Candida biofilm.
由念珠菌属（spp.）在医疗器械上形成的生物膜是潜在的健康风险。目前的研究重点是寻找新的方法来治疗和预防生物膜相关感染，包括使用现代纳米技术等不同方法。本综述总结了目前关于念珠菌属（主要是白色念珠菌）对抗生素耐药/耐受机制的最新信息，以及导致这些现象的其他因素的作用。此外，还提供了关于预防和清除念珠菌生物膜的信息更新，包括“锁”疗法的经验、小分子在生物医学应用中的潜在利用以及光动力失活在控制念珠菌生物膜中的应用前景。
