Li Xingxing, Lei Xuan, Zhang Cong, Jiang Zhibo, Shi Yuanyuan, Wang Songmei, Wang Lifei, Hong Bin
Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Biotechnol. 2016 Mar 20;222:9-10. doi: 10.1016/j.jbiotec.2016.02.004. Epub 2016 Feb 4.
Streptomyces globisporus C-1027 produces a nine-membered enediyne antitumor antibiotic lidamycin. Here we report the complete genome sequence of S. globisporus C-1027, which consists of a 7,608,611 bp linear chromosome, a 167,754 bp linear plasmid SGLP1 and a 7,234 bp circular plasmid pSGL1. The biosynthetic gene cluster for lidamycin was located in the linear plasmid SGLP1. Genome analysis also revealed a number of genes related to biosynthesis of diverse secondary metabolites. The genome sequence of C-1027 will enable us to disclose biosynthetic pathways of these secondary metabolites and discover new natural products with potential applications notably in human health.
球形孢链霉菌C-1027产生一种九元烯二炔类抗肿瘤抗生素力达霉素。在此，我们报道球形孢链霉菌C-1027的完整基因组序列，其由一条7,608,611 bp的线性染色体、一条167,754 bp的线性质粒SGLP1和一条7,234 bp的环状质粒pSGL1组成。力达霉素的生物合成基因簇位于线性质粒SGLP1中。基因组分析还揭示了许多与多种次级代谢产物生物合成相关的基因。C-1027的基因组序列将使我们能够揭示这些次级代谢产物的生物合成途径，并发现具有潜在应用价值的新天然产物，尤其是在人类健康领域。
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