Ma Wei-Guo, Zhang Wei, Wang Long-Fei, Zheng Jun, Ziganshin Bulat A, Charilaou Paris, Pan Xu-Dong, Liu Yong-Min, Zhu Jun-Ming, Chang Qian, Rizzo John A, Elefteriades John A, Sun Li-Zhong
Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, and Beijing Engineering Research Center of Vascular Prostheses, Beijing, China; Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China; Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Conn.
Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, and Beijing Engineering Research Center of Vascular Prostheses, Beijing, China.
J Thorac Cardiovasc Surg. 2016 Jun;151(6):1581-92. doi: 10.1016/j.jtcvs.2015.11.056. Epub 2015 Dec 13.
To evaluate the efficacy of the frozen elephant trunk (FET) and total arch replacement (TAR) technique (FET + TAR) in the management of type A aortic dissection (TAAD) with arch entry tear.
Clinical outcomes were analyzed for 104 TAAD patients with arch entry tear undergoing FET + TAR at 4.7 ± 3.5 days from symptom onset and compared with 728 TAAD patients with entry tears in elsewhere. The mean patient age was 49.3 ± 9.3 years, compared with 45.6 ± 10.8 years in other TAAD patients (P < .001). There were 84 men (80.8%). Hypertension was seen in 84.6% (88/104).
Operative mortality was 8.6% (9/104). Spinal cord injury occurred in 3 cases (2.9%), stroke in 2 (1.9%), renal failure in 4 (3.8%) and limb ischemia in 2 (1.9%). Follow-up was 100% (95/95) at mean 5.6 ± 2.6 years (range 1.3-11.6). Late death occurred in 2 cases (1.9%). Survival and freedom from late adverse events were 89.2% (95% confidence interval [CI], 81.3%-93.9%) and 85.0% (95% CI, 76.3%-90.8%) at 8 years, respectively. Both the stented and unstented distal aortic segments showed significant trends of false lumen shrinkage and true lumen expansion over time (P < .001). Of the 65 CT scans at mean 4.6 ± 2.9 years postoperatively, the false lumen was completely obliterated in 63. Risk factors for arch entry tear were hypertension (odds ratio [OR], 2.091; 95% CI, 1.186-3.687; P = .011) and age (OR, 1.025; 95% CI, 1.002-1.048; P = .032).
TAAD with arch entry tear was treated safely and durably by FET + TAR. Although patients with arch entry tear were somewhat older than other patients, operative mortality was not substantially higher despite their older age and arch location of entry tear. These results argue favorably for the use of the FET + TAR technique in the management of TAAD patients with arch entry tears.
评估冷冻象鼻支架(FET)联合全主动脉弓置换术(TAR)(FET + TAR)治疗合并主动脉弓入口撕裂的A型主动脉夹层(TAAD)的疗效。
分析104例合并主动脉弓入口撕裂的TAAD患者在症状出现后4.7±3.5天接受FET + TAR治疗的临床结果,并与728例其他部位存在入口撕裂的TAAD患者进行比较。患者平均年龄为49.3±9.3岁,其他TAAD患者平均年龄为45.6±10.8岁(P <.001)。男性84例(80.8%)。84.6%(88/104)的患者患有高血压。
手术死亡率为8.6%(9/104)。3例(2.9%)发生脊髓损伤,2例(1.9%)发生中风,4例(3.8%)发生肾衰竭,2例(1.9%)发生肢体缺血。平均随访5.6±2.6年(范围1.3 - 11.6年),随访率为100%(95/95)。2例(1.9%)发生晚期死亡。8年时的生存率和无晚期不良事件生存率分别为89.2%(95%置信区间[CI],81.3% - 93.9%)和85.0%(95%CI,76.3% - 90.8%)。带支架和不带支架的主动脉远端节段均显示假腔随时间有明显缩小和真腔扩张的趋势(P <.001)。术后平均4.6±2.9年的65例CT扫描中,63例假腔完全闭塞。主动脉弓入口撕裂的危险因素为高血压(比值比[OR],2.091;95%CI,1.186 - 3.687;P =.011)和年龄(OR,1.025;95%CI,1.002 - 1.048;P =.032)。
FET + TAR能安全、持久地治疗合并主动脉弓入口撕裂的TAAD。虽然合并主动脉弓入口撕裂的患者年龄比其他患者稍大,但尽管其年龄较大且入口撕裂位于主动脉弓,手术死亡率并未显著更高。这些结果有力地支持了FET + TAR技术用于治疗合并主动脉弓入口撕裂的TAAD患者。