碱金属离子对蛋白质和核酸成分的区分特性。气相和理论研究的结论

Discriminating Properties of Alkali Metal Ions Towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies.

作者信息

Rodgers Mary T, Armentrout Peter B

机构信息

Department of Chemistry, Wayne State University, Detroit, MI, 48202, USA.

Department of Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.

出版信息

Met Ions Life Sci. 2016;16:103-31. doi: 10.1007/978-3-319-21756-7_4.

DOI:10.1007/978-3-319-21756-7_4

PMID:26860300

Abstract

Quantitative insight into the structures and thermodynamics of alkali metal cations interacting with biological molecules can be obtained from studies in the gas phase combined with theoretical work. In this chapter, the fundamentals of the experimental and theoretical techniques are first summarized and results for such work on complexes of alkali metal cations with amino acids, small peptides, and nucleobases are reviewed. Periodic trends in how these interactions vary as the alkali metal cations get heavier are highlighted.

摘要

通过气相研究与理论工作相结合，可以对碱金属阳离子与生物分子相互作用的结构和热力学进行定量洞察。在本章中，首先总结了实验和理论技术的基本原理，并综述了关于碱金属阳离子与氨基酸、小肽和核碱基形成的配合物的此类研究结果。着重强调了随着碱金属阳离子变重，这些相互作用如何变化的周期性趋势。