Padera Timothy P, Meijer Eelco F J, Munn Lance L
Edwin L. Steele Laboratories, Department of Radiation Oncology, and Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; email:
Annu Rev Biomed Eng. 2016 Jul 11;18:125-58. doi: 10.1146/annurev-bioeng-112315-031200. Epub 2016 Feb 5.
Advances in our understanding of the structure and function of the lymphatic system have made it possible to identify its role in a variety of disease processes. Because it is involved not only in fluid homeostasis but also in immune cell trafficking, the lymphatic system can mediate and ultimately alter immune responses. Our rapidly increasing knowledge of the molecular control of the lymphatic system will inevitably lead to new and effective therapies for patients with lymphatic dysfunction. In this review, we discuss the molecular and physiological control of lymphatic vessel function and explore how the lymphatic system contributes to many disease processes, including cancer and lymphedema.
我们对淋巴系统结构和功能认识的进展,使我们能够确定其在多种疾病过程中的作用。由于淋巴系统不仅参与体液平衡,还参与免疫细胞运输,因此它可以介导并最终改变免疫反应。我们对淋巴系统分子调控的了解迅速增加,这将不可避免地为淋巴功能障碍患者带来新的有效治疗方法。在这篇综述中,我们讨论淋巴管功能的分子和生理调控,并探讨淋巴系统如何促成包括癌症和淋巴水肿在内的许多疾病过程。