Abbott Sabra M, Videnovic Aleksandar
Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nat Sci Sleep. 2016 Jan 25;8:55-61. doi: 10.2147/NSS.S78947. eCollection 2016.
Sleep-wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep-wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However, in addition to being a symptom of the underlying neurodegenerative condition, there is also emerging evidence that sleep disturbance itself may contribute to the development and facilitate the progression of several of these disorders. Due to its impact both as an early symptom and as a potential factor contributing to ongoing neurodegeneration, the sleep-wake cycle is an ideal target for further study for potential interventions not only to lessen the burden of these diseases but also to slow their progression. In this review, we will highlight the sleep phenotypes associated with some of the major neurodegenerative disorders, focusing on the circadian disruption associated with Alzheimer's disease, the rapid eye movement behavior disorder and sleep fragmentation associated with Parkinson's disease, and the insomnia and circadian dysregulation associated with Huntington's disease.
睡眠-觉醒紊乱经常被观察到，并且常常是许多神经退行性疾病最早报告的症状之一。这为了解这些疾病的潜在病理生理学提供了线索，因为睡眠-觉醒异常通常伴随着神经退行性变或神经递质变化。然而，除了是潜在神经退行性疾病的症状外，也有新出现的证据表明睡眠障碍本身可能促进这些疾病中的几种疾病的发展并加速其进展。由于其作为早期症状以及作为导致持续神经退行性变的潜在因素的影响，睡眠-觉醒周期是进一步研究潜在干预措施的理想靶点，这些干预措施不仅可以减轻这些疾病的负担，还可以减缓其进展。在这篇综述中，我们将重点介绍与一些主要神经退行性疾病相关的睡眠表型，重点关注与阿尔茨海默病相关的昼夜节律紊乱、与帕金森病相关的快速眼动行为障碍和睡眠片段化，以及与亨廷顿舞蹈病相关的失眠和昼夜节律失调。
