ω-3脂肪酸对卫星细胞生肌程序的潜在作用。
Potential Role of Omega-3 Fatty Acids on the Myogenic Program of Satellite Cells.
作者信息
Bhullar Amritpal S, Putman Charles T, Mazurak Vera C
机构信息
M.Sc, Faculty of Agricultural, Life, and Environmental Science, Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, Canada.
PhD, Associate Professor, Faculty of Physical Education and Recreation and Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
出版信息
Nutr Metab Insights. 2016 Feb 3;9:1-10. doi: 10.4137/NMI.S27481. eCollection 2016.
Skeletal muscle loss is associated with aging as well as pathological conditions. Satellite cells (SCs) play an important role in muscle regeneration. Omega-3 fatty acids are widely studied in a variety of muscle wasting diseases; however, little is known about their impact on skeletal muscle regeneration. The aim of this review is to evaluate studies examining the effect of omega-3 fatty acids, α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid on the regulation of SC proliferation and differentiation. This review highlights mechanisms by which omega-3 fatty acids may modulate the myogenic program of the stem cell population within skeletal muscles and identifies considerations for future studies. It is proposed that minimally three myogenic transcriptional regulatory factors, paired box 7 (Pax7), myogenic differentiation 1 protein, and myogenin, should be measured to confirm the stage of SCs within the myogenic program affected by omega-3 fatty acids.
骨骼肌损失与衰老以及病理状况相关。卫星细胞（SCs）在肌肉再生中发挥重要作用。ω-3脂肪酸在多种肌肉萎缩疾病中得到广泛研究；然而，它们对骨骼肌再生的影响却知之甚少。本综述的目的是评估研究ω-3脂肪酸、α-亚麻酸、二十碳五烯酸和二十二碳六烯酸对卫星细胞增殖和分化调节作用的相关研究。本综述强调了ω-3脂肪酸可能调节骨骼肌内干细胞群体肌源性程序的机制，并确定了未来研究的注意事项。建议至少测量三种肌源性转录调节因子，即配对盒7（Pax7）、肌源性分化1蛋白和肌细胞生成素，以确认受ω-3脂肪酸影响的卫星细胞在肌源性程序中的阶段。
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