韩国通气功能正常受试者血清脂肪酸结合蛋白4水平与肺功能的关系。
The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function.
作者信息
Park Hye-Jeong, Park Se Eun, Park Cheol-Young, Lim Seong Yong, Lee Won-Young, Oh Ki-Won, Park Sung-Woo, Rhee Eun-Jung
机构信息
Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
BMC Pulm Med. 2016 Feb 18;16:34. doi: 10.1186/s12890-016-0190-8.
BACKGROUND
The aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults.
METHODS
In 495 participants in a health screening program, Force Exploratory Volume (FEV) 1 and Forced Vital Capacity (FVC) were assessed with standard spirometry. Subjects with obstructive (n = 19) and restrictive (n = 45) lung function were excluded from the analysis. Serum FABP4 level was measured by enzyme-linked immunosorbent assay and transformed into Ln(FABP4). 431 subjects with normal ventilator function (72.4% men, mean age 41 years) were included in the final analysis.
RESULTS
Mean Ln(FABP4) significantly decreased in subjects from 1(st) quartile to 4(th) quartile of FVC (p = 0.008). Ln(FABP4) did not show significant differences across the quartile groups of FEV1. The odds ratio (OR) of being in the lowest quartile of FVC was 2.704 in subject with 3(rd) tertile of Ln(FABP4) after full adjustment for confounding variables {95% confidence interval (CI) 1.397 ~ 5.357}. OR of being in the lowest quartile of FEV1 was 1.822 (95% CI 1.021 ~ 3.298) in subjects with 3(rd) tertile of Ln(FABP4) after adjustment of age and sex, which was attenuated after full adjustment for confounding variables.
CONCLUSION
Increased FABP4 level showed increased risk for reduced lung function in subjects with normal ventilatory function.
背景
本研究旨在评估在表面健康的韩国成年人中肺功能与血清脂肪酸结合蛋白4（FABP4）之间的关联。
方法
在一项健康筛查项目的495名参与者中，采用标准肺量计评估用力呼气容积（FEV）1和用力肺活量（FVC）。分析中排除了具有阻塞性（n = 19）和限制性（n = 45）肺功能的受试者。通过酶联免疫吸附测定法测量血清FABP4水平，并将其转换为Ln（FABP4）。最终分析纳入了431名通气功能正常的受试者（72.4%为男性，平均年龄41岁）。
结果
FVC处于第1四分位数至第4四分位数的受试者中，平均Ln（FABP4）显著降低（p = 0.008）。Ln（FABP4）在FEV1的四分位数组之间未显示出显著差异。在对混杂变量进行完全调整后，Ln（FABP4）处于第3三分位数的受试者中，FVC处于最低四分位数的比值比（OR）为2.704{95%置信区间（CI）1.3975.357}。在调整年龄和性别后，Ln（FABP4）处于第3三分位数的受试者中，FEV1处于最低四分位数的OR为1.822（95%CI 1.0213.298），在对混杂变量进行完全调整后该值减弱。
结论
在通气功能正常的受试者中，FABP4水平升高表明肺功能降低的风险增加。
Zotero 插件