美国男性和女性中银屑病表型的患病率。
Prevalence of psoriasis phenotypes among men and women in the USA.
作者信息
Merola J F, Li T, Li W-Q, Cho E, Qureshi A A
机构信息
Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Division of Rheumatology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
出版信息
Clin Exp Dermatol. 2016 Jul;41(5):486-9. doi: 10.1111/ced.12805. Epub 2016 Feb 18.
BACKGROUND
We present the largest set of US prevalence data for psoriasis to date, obtained from three prospective cohort studies describing validated clinical phenotypes of psoriasis, including novel data about the prevalence of inverse (intertriginous) psoriasis in these groups. Nonplaque psoriasis phenotypes have been largely unmeasured in observational and interventional studies, and this has led to an under-recognition of this aspect of psoriatic disease.
AIM
To describe the prevalence of nonplaque psoriasis phenotypes in a large prospective cohort.
METHODS
We included 3179 women and 646 men in the analysis. Participants in the Nurses Health Study (NHS) and Health Professionals Follow-up Study (HPFS) with physician-diagnosed psoriasis completed a validated, self-administered questionnaire to assess plaque and nonplaque subsets of psoriasis.
RESULTS
Psoriasis phenotypes were as follows: plaque 55%, scalp 52%, palmar-plantar 14%, nail 23% and inverse 21% in the NHS (n = 1604); plaque 60%, scalp 56%, palmar-plantar 16%, nail 27% and inverse 24% in the second NHS study (NHS II) (n = 1575); and plaque 55%, scalp 45%, palmar-plantar 12%, nail 27% and inverse 30% in the HPFS (n = 646). Scalp, nail, palmar-plantar and inverse disease represent highly prevalent phenotypes of psoriasis in the USA.
CONCLUSION
Scalp, nail, palmar-plantar and inverse disease represent highly prevalent phenotypes of psoriasis.
背景
我们展示了迄今为止美国最大规模的银屑病患病率数据，这些数据来自三项前瞻性队列研究，描述了经过验证的银屑病临床表型，包括这些组中关于反向（间擦部位）银屑病患病率的新数据。在观察性和干预性研究中，非斑块型银屑病表型大多未得到测量，这导致对银屑病这一方面的认识不足。
目的
描述大型前瞻性队列中非斑块型银屑病表型的患病率。
方法
我们纳入了3179名女性和646名男性进行分析。护士健康研究（NHS）和卫生专业人员随访研究（HPFS）中被医生诊断为银屑病的参与者完成了一份经过验证的自我管理问卷，以评估银屑病的斑块型和非斑块型亚组。
结果
在NHS（n = 1604）中，银屑病表型如下：斑块型55%，头皮型52%，掌跖型14%，甲型23%，反向型21%；在第二项NHS研究（NHS II）（n = 1575）中，斑块型60%，头皮型56%，掌跖型16%，甲型27%，反向型24%；在HPFS（n = 646）中，斑块型55%，头皮型45%，掌跖型12%，甲型27%，反向型30%。头皮、甲、掌跖和反向疾病是美国银屑病的高度流行表型。
结论
头皮、甲、掌跖和反向疾病是银屑病的高度流行表型。
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