Are HLA-E*0103 alleles predictive markers for nasopharyngeal cancer risk?
作者信息
Douik Hayet, Romdhane Neila Attia, Guemira Fethi
机构信息
Clinical Biology Department, Salah Azaiz Institute of Cancer, 1006 Bab Saadoun, Tunis, Tunisia.
Statistic and Epidemiology Department, Faculty of Medicine, 1007, Djebel Lakhdar, La Rabta, Tunis, Tunisia.
出版信息
Pathol Res Pract. 2016 Apr;212(4):345-9. doi: 10.1016/j.prp.2016.01.010. Epub 2016 Feb 2.
BACKGROUND
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer, tightly related to Epstein-Barr virus infection and thus to HLA genes. In this study, we aimed to analyze HLA-E polymorphism in NPC advent and prognosis. 130 unrelated patients with CNP and 180 unrelated and healthy controls were included in our study. HLA-E genotyping was performed by PCR/RFLP method; SPSS (13.0) was used for statistical analysis, and survival curbs were established with the "Kaplan-Meier" method (Log Rank<0.05).
RESULTS
We found a significant difference within HLA-E103 variants between patients and controls: E1031 and E1032 were associated with CNP (OR=1.613, p=0.013 and OR=1.0809, p=0.055), and E1033 with controls (OR=0.254, p<10(-4)).
CONCLUSION
Our study reveals that HLA-E polymorphism is associated with nasopharyngeal cancer. HLA-E expression studies could be used to understand the implication of E*103 variants.
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