转运RNA片段：代际遗传中的新角色。
tRNA fragments: novel players in intergenerational inheritance.
作者信息
Gapp Katharina, Miska Eric A
机构信息
The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
出版信息
Cell Res. 2016 Apr;26(4):395-6. doi: 10.1038/cr.2016.24. Epub 2016 Feb 23.
Abstract
Non-genetic inheritance is an evocative topic; in the past few years, the debate around potential inheritance of life-time experiences independent of social factors in mammals has become highly prominent due to increasing evidence for phenotypes in the offspring after paternal environmental exposures. Strikingly, two independent studies published in Science newly implicate a special class of RNA, transfer RNA fragments, in the intergenerational effects of paternal dietary intervention.
摘要
非遗传继承是一个引人关注的话题；在过去几年里，围绕哺乳动物中独立于社会因素的终身经历的潜在继承的争论变得非常突出，这是由于越来越多的证据表明父本环境暴露后后代会出现表型。引人注目的是，发表在《科学》杂志上的两项独立研究新近表明，一类特殊的RNA，即转运RNA片段，在父本饮食干预的代际效应中发挥作用。
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