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[重视精准医学在眼科中的应用]

[Emphasis on the application of precision medicine in ophthalmology].

作者信息

Sun X D, Zhu H

机构信息

Department of Ophthalmology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2016 Feb;52(2):85-8. doi: 10.3760/cma.j.issn.0412-4081.2016.02.002.

Abstract

Accompany with dramatically growth of large-scale biological databases (such as human genome sequence), improvement of life science and development of international clinical trials, science offers great potential for improving health care through precision medicine. As a hot topic recently, precision medicine might launch a revolution of the methodology in medical research. How to achieve precision medicine in clinical ophthalmology by means of biological data mining is a challenge for ophthalmologist-scientists. The best approach for advanced individual medicine is to buildup the digital ophthalmology, which includes human eye biobank, national biological databases network, clinical department, basic research lab, and international clinical trial center. The system of digital ophthalmology could explore the methods for ophthalmology research, integrate the source of eye biologic databases, promote international cooperation, and thus eventually supply the opportunity for translational medicine.

摘要

随着大规模生物数据库(如人类基因组序列)的急剧增长、生命科学的进步以及国际临床试验的发展,科学为通过精准医学改善医疗保健提供了巨大潜力。作为近期的一个热门话题,精准医学可能会引发医学研究方法的一场革命。对于眼科科学家来说,如何通过生物数据挖掘在临床眼科中实现精准医学是一项挑战。实现先进个体化医学的最佳方法是建立数字眼科,其中包括人眼生物样本库、国家生物数据库网络、临床科室、基础研究实验室和国际临床试验中心。数字眼科系统可以探索眼科研究方法,整合眼生物数据库资源,促进国际合作,从而最终为转化医学提供机会。

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