白细胞介素1A基因中的功能性插入/缺失多态性与降低乳腺癌风险相关。
A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.
作者信息
Huang X, Yang Y, Cui Z W, Wang J, Gao L B
机构信息
Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.
Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
出版信息
Genet Mol Res. 2016 Feb 11;15(1):gmr7486. doi: 10.4238/gmr.15017486.
The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism. The ins/ins (ttca/ttca) genotype was significantly associated with a decreased risk of BC compared with the del/del (-/-) genotype (OR = 0.48, 95% CI = 0.27-0.85). Moreover, the ins (ttca) allele distribution between cases and controls was significantly different from the del (-) allele distribution (OR = 0.74, 95% CI = 0.57-0.96). Thus, the rs3783553 polymorphism is associated with a decreased incidence of breast cancer.
白细胞介素 -1A（IL1A）3'非翻译区的插入/缺失多态性（rs3783553 TTCA/-）已得到深入研究，并已证明其会影响肿瘤风险。我们研究了IL1A基因多态性rs3783553的频率，并评估了其与乳腺癌（BC）的关系。开展了一项基于医院的病例对照研究，该研究纳入了228例经组织学确诊的BC患者和241名健康受试者。采用聚合酶链反应检测IL1A rs3783553多态性。与del/del（-/-）基因型相比，ins/ins（ttca/ttca）基因型与BC风险降低显著相关（OR = 0.48，95% CI = 0.27 - 0.85）。此外，病例组和对照组之间ins（ttca）等位基因分布与del（-）等位基因分布存在显著差异（OR = 0.74，95% CI = 0.57 - 0.96）。因此，rs3783553多态性与乳腺癌发病率降低相关。
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