[血液系统恶性肿瘤中长链非编码RNA的研究进展——综述]
[Research Progress on Long Non-Coding RNA in Hematological Malignancies--Review].
作者信息
Xin Liu-Yan, Zhong Si-Si, Liu Ai-Fei, Chen Yi-Jian
机构信息
Department of Hematology, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China.
Medical Postgraduated School of Nanchang University, Nanchang 330003, Jiangxi Province, China.
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Feb;24(1):237-40. doi: 10.7534/j.issn.1009-2137.2016.01.045.
Long non-coding RNA (LncRNA) is defined as a class of transcripts more than 200 nucleotides in length and without the protein-coding function. It has been found for years, however, that little is known about the potential role of LncRNA in humans. But recent studies showed that LncRNA can regulate the coding-gene expression and participate in effects of human body. Accumulating evidence demonstrated that LncRNA are involved in cancer incidence, development and progression.With further exploration on the mechanisms of tumors, the relationship between the long non-coding RNA and hematological malignancies increasingly become a hot research. This review focuses on the mechanisms of LncRNA in hematological malignancies.
长链非编码RNA（LncRNA）被定义为一类长度超过200个核苷酸且无蛋白质编码功能的转录本。然而，多年来人们发现对LncRNA在人类中的潜在作用知之甚少。但最近的研究表明，LncRNA可以调节编码基因的表达并参与人体的各种效应。越来越多的证据表明，LncRNA参与癌症的发生、发展和进展。随着对肿瘤机制的进一步探索，长链非编码RNA与血液系统恶性肿瘤之间的关系日益成为研究热点。本综述重点关注LncRNA在血液系统恶性肿瘤中的作用机制。
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