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对于所有患者而言,勒孔特技术是大动脉转位修复的最终解决方案吗?一项术后二十年的磁共振成像研究,其中包括螺旋技术。

Is the Lecompte technique the last word on transposition of the great arteries repair for all patients? A magnetic resonance imaging study including a spiral technique two decades postoperatively.

作者信息

Rickers Carsten, Kheradvar Arash, Sievers Hans-Hinrich, Falahatpisheh Ahmad, Wegner Philip, Gabbert Dominik, Jerosch-Herold Michael, Hart Chris, Voges Inga, Putman Léon M, Kristo Ines, Fischer Gunther, Scheewe Jens, Kramer Hans-Heiner

机构信息

Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany

University of California Irvine, Edwards Lifesciences Center of Advanced Cardiovascular Technology, Irvine, CA, USA.

出版信息

Interact Cardiovasc Thorac Surg. 2016 Jun;22(6):817-25. doi: 10.1093/icvts/ivw014. Epub 2016 Feb 25.

Abstract

OBJECTIVES

To compare the Lecompte technique and the spiral anastomosis (complete anatomic correction) two decades after arterial switch operation (ASO).

METHODS

Nine patients after primary ASO with Lecompte and 6 selected patients after spiral anastomosis were evaluated 20.8 ± 2.1 years after ASO versus matched controls. Blood flow dynamics and flow profiles (e.g. vorticity, helicity) in the great arteries were quantified from time-resolved 3D magnetic resonance imaging (MRI) phase contrast flow measurements (4D flow MR) in addition to a comprehensive anatomical and functional cardiovascular MRI analysis.

RESULTS

Compared with spiral reconstruction, patients with Lecompte showed more vortex formation, supranatural helical blood flow (relative helicity in aorta: 0.036 vs 0.089; P < 0.01), a reduced indexed cross-sectional area of the left pulmonary artery (155 vs 85 mm²/m²; P < 0.001) and more semilunar valve dysfunctions (n = 5 vs 1). There was no difference in elastic aortic wall properties, ventricular function, myocardial perfusion and myocardial fibrosis between the two groups. Cross-sectional area of the aortic sinus was larger in patients than in controls (669 vs 411 mm²/m²; P < 0.01). In the spiral group, the pulmonary root was rotated after ASO more towards the normal left position (P < 0.01).

CONCLUSIONS

In this study, selected patients with spiral anastomoses showed, two decades after ASO, better physiologically adapted blood flow dynamics, and attained a closer to normal anatomical position of their great arteries, as well as less valve dysfunction. Considering the limitations related to the small number of patients and the novel MRI imaging techniques, these data may provoke reconsidering the optimal surgical approaches to transposition of the great arteries repair.

摘要

目的

比较动脉调转术(ASO)二十年后的Lecompte技术和螺旋吻合术(完全解剖矫正)。

方法

对9例初次行ASO采用Lecompte技术的患者和6例采用螺旋吻合术的选定患者在ASO术后20.8±2.1年进行评估,并与匹配的对照组进行比较。除了全面的解剖和功能心血管磁共振成像分析外,还通过时间分辨三维磁共振成像(MRI)相位对比血流测量(四维血流磁共振)对大动脉中的血流动力学和血流剖面(如涡度、螺旋度)进行量化。

结果

与螺旋重建相比,采用Lecompte技术的患者表现出更多的涡流形成、超自然螺旋血流(主动脉相对螺旋度:0.036对0.089;P<0.01)、左肺动脉指数横截面积减小(155对85mm²/m²;P<0.001)以及更多的半月瓣功能障碍(n=5对1)。两组之间在弹性主动脉壁特性、心室功能、心肌灌注和心肌纤维化方面无差异。患者的主动脉窦横截面积大于对照组(669对411mm²/m²;P<0.01)。在螺旋组中,ASO术后肺动脉根部更向正常左侧位置旋转(P<0.01)。

结论

在本研究中,选定的采用螺旋吻合术的患者在ASO术后二十年表现出更好的生理适应性血流动力学,其大动脉解剖位置更接近正常,瓣膜功能障碍也更少。考虑到与患者数量少和新型MRI成像技术相关的局限性,这些数据可能会促使人们重新考虑大动脉转位修复的最佳手术方法。

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