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儿童无症状下极结石的结局分析。

Outcome Analysis of Asymptomatic Lower Pole Stones in Children.

机构信息

Division of Urology, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Division of Nephrology, Department of Pediatrics (EH), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Division of Urology, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Division of Nephrology, Department of Pediatrics (EH), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

出版信息

J Urol. 2016 Apr;195(4 Pt 2):1289-93. doi: 10.1016/j.juro.2015.11.038. Epub 2016 Feb 28.

Abstract

PURPOSE

Lower pole renal stones in children usually present incidentally. To our knowledge frequency and need for intervention are unknown. We evaluated the outcomes of asymptomatic, incidentally found lower pole renal stones in children.

MATERIALS AND METHODS

We retrospectively reviewed the charts and renal ultrasounds of children with lower pole stones seen during a period of 14 years. The unpaired t-test was used to determine factors that might predict the need for stone intervention, including size, growth rate, type of stone and underlying metabolic disease. The success rate of nonoperative management, defined by spontaneous passage or lack of growth in the absence of symptoms, was calculated.

RESULTS

A total of 224 children were found to have lower pole stones. Mean ± SD age at presentation was 95.2 ± 65.3 months. Of the patients 120 (53.6%) spontaneously passed stones. Of the stones 25% remained asymptomatic and did not grow with time. Intervention was performed in 48 children (21.4%). Stones originally managed conservatively that later required intervention were significantly larger at baseline than stones that did not require intervention through the end of followup (median 7 vs 5 mm, p <0.001) and those that grew with time (median stone size 8 mm at surgical intervention, p = 0.01).

CONCLUSIONS

Our data suggest that asymptomatic lower pole renal stones can be followed conservatively. Of the calculi 78.6% passed spontaneously or remained asymptomatic and did not grow. Median initial size greater than 7 mm and stone growth with time were significant risk factors that predicted the need for intervention.

摘要

目的

儿童下极肾结石通常是偶然发现的。据我们所知,其发生频率和干预需求尚不清楚。我们评估了无症状、偶然发现的儿童下极肾结石的结局。

材料与方法

我们回顾性分析了 14 年间就诊的下极结石患儿的病历和肾脏超声结果。采用配对 t 检验确定可能预测结石干预需求的因素,包括大小、生长速度、结石类型和潜在代谢性疾病。无结石干预(定义为自发排出或无症状且无生长)的成功率通过计算得出。

结果

共发现 224 例儿童患有下极结石。就诊时的平均年龄为 95.2 ± 65.3 个月。120 例患者(53.6%)结石自行排出。25%的患者无症状且结石随时间无变化。48 例患者(21.4%)接受了干预。最初接受保守治疗但随后需要干预的结石,其基线大小明显大于无需干预至随访结束的结石(中位数 7 比 5mm,p<0.001)和随时间生长的结石(中位数结石大小在手术干预时为 8mm,p=0.01)。

结论

我们的数据表明,无症状的下极肾结石可保守治疗。78.6%的结石自发排出或无症状且不生长。初始大小中位数大于 7mm 和结石随时间生长是需要干预的显著风险因素。

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