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减少严重精神疾病中攻击行为和暴力的非药物干预措施:一项系统评价与叙述性综合分析

Non-pharmacological interventions for reducing aggression and violence in serious mental illness: A systematic review and narrative synthesis.

作者信息

Rampling J, Furtado V, Winsper C, Marwaha S, Lucca G, Livanou M, Singh S P

机构信息

Birmingham and Solihull Mental Health NHS Foundation Trust, c/o Reaside Clinic, Birmingham, UK.

Birmingham and Solihull Mental Health NHS Foundation Trust, c/o Reaside Clinic, Birmingham, UK; Department of Mental Health and Wellbeing, Warwick Medical School, University of Warwick CV4 7AL, UK.

出版信息

Eur Psychiatry. 2016 Apr;34:17-28. doi: 10.1016/j.eurpsy.2016.01.2422. Epub 2016 Feb 27.

Abstract

BACKGROUND

For people with mental illness that are violent, a range of interventions have been adopted with the aim of reducing violence outcomes. Many of these interventions have been borrowed from other (offender) populations and their evidence base in a Serious Mental Illness (SMI) population is uncertain.

AIMS

To aggregate the evidence base for non-pharmacological interventions in reducing violence amongst adults with SMI and PD (Personality Disorder), and to assess the efficacy of these interventions. We chose to focus on distinct interventions rather than on holistic service models where any element responsible for therapeutic change would be difficult to isolate.

METHODS

We performed a systematic review and narrative synthesis of non-pharmacological interventions intended to reduce violence in a SMI population and in patients with a primary diagnosis of PD. Five online databases were searched alongside a manual search of seven relevant journals, and expert opinion was sourced. Eligibility of all returned articles was independently assessed by two authors, and quality of studies was appraised via the Cochrane Collaboration Tool for Assessing Risk of Bias.

RESULTS

We included 23 studies of diverse psychological and practical interventions, with a range of experimental and quasi-experimental study designs that included 7 Randomised Controlled Trials (RCTs). The majority were studies of Mentally Disordered Offenders. The stronger evidence existed for patients with a SMI diagnosis receiving Cognitive Behavioural Therapy or modified Reasoning & Rehabilitation (R&R). For patients with a primary diagnosis of PD, a modified version of R&R appeared tolerable and Enhanced Thinking Skills showed some promise in improving attitudes over the short-term, but studies of Dialectical Behaviour Therapy in this population were compromised by high risk of experimental bias. Little evidence could be found for non-pharmacological, non-psychological interventions.

CONCLUSIONS

The evidence for non-pharmacological interventions for reducing violence in this population is not conclusive. Long-term outcomes are lacking and good quality RCTs are required to develop a stronger evidence base.

摘要

背景

对于有暴力行为的精神疾病患者,已采用一系列干预措施以降低暴力事件的发生。其中许多干预措施借鉴自其他(罪犯)群体,其在严重精神疾病(SMI)患者群体中的证据基础尚不明确。

目的

汇总非药物干预措施在减少成年SMI和人格障碍(PD)患者暴力行为方面的证据基础,并评估这些干预措施的疗效。我们选择专注于不同的干预措施,而非整体服务模式,因为在整体服务模式中,难以分离出任何负责治疗性改变的因素。

方法

我们对旨在减少SMI患者群体以及原发性PD患者暴力行为的非药物干预措施进行了系统综述和叙述性综合分析。除了对7种相关期刊进行手工检索外,还搜索了5个在线数据库,并获取了专家意见。两位作者独立评估所有检索到的文章的 eligibility,研究质量通过Cochrane协作偏倚风险评估工具进行评估。

结果

我们纳入了23项关于各种心理和实践干预措施的研究,采用了一系列实验性和准实验性研究设计,其中包括7项随机对照试验(RCT)。大多数是对精神错乱罪犯的研究。对于诊断为SMI的患者,接受认知行为疗法或改良的推理与康复(R&R)有更强的证据。对于原发性PD诊断的患者,改良版的R&R似乎是可耐受的,增强思维技能在短期内改善态度方面显示出一些前景,但该人群中辩证行为疗法的研究因实验偏倚风险高而受到影响。对于非药物、非心理干预措施,几乎找不到证据。

结论

该人群中减少暴力行为的非药物干预措施的证据尚无定论。缺乏长期结果,需要高质量的RCT来建立更强的证据基础。

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